IMPROVEMENT OF REQUIREMENTS FOR THE QUALITY OF CARAWAY (CARUM CARVI) FRUITS

Download full text PDF
DOI: https://doi.org/None
Issue: 
5
Year: 
2017

Professor I.A. Samylina, PhD; V.M. Baeva, PhD ; R.M. Kuznetsov, PhD I.M. Sechenov First Moscow State Medical University; 2, B. Pirogovskaya St., Build. 4, Moscow 119991, Russian Federation

Introduction. Caraway (Carum carvi) fruits are included in the pharmacopoeias of many countries as an antifloaming agent for flatulence and also used as a component in gastric herbal teas. The current documentation governing the quality of the raw material needs to be improved. Objective: to conduct an in-depth pharmacognostic study of caraway fruits to specify and amend regulatory requirements for the raw material. Material and methods. The investigation object was commercial samples of the medicinal plant raw material of caraway fruits. Pharmacognostic analysis of the raw materials, thin-layer chromatography (TLC), and gas-liquid chromatography with mass spectroscopy (GLC-MS) were used. Results. The morphological and anatomical characteristics of crushed caraway fruits were given. Procedures were developed for chromatographic identification (TLC and GLC-MS) of the components of essential oil from caraway fruits. The requirements characterizing the safety of the raw material of caraway fruits were additionally stated. Conclusion. The results of the investigation have enabled the authors to elaborate a draft pharmacopoeia article on caraway fruits, which meets the pharmacopoieal requirements for herbal pharmaceutical substances.
Keywords: 
caraway
Carum carvi L.
fruits
quality control
improvement of requirements
References: 
  1. Gosudarstvennyy reestr lekarstvennyh sredstv. Tom 2, ch.1,2. M.: Medicinskiy sovet, 2009; ch.1: 568; ch.2: 560.
  2. Rastitel`nye resursy SSSR. Tom 4. Cvetkovye rasteniya, ih himicheskiy sostav, ispol`zovanie. Semeystva Rutaceae – Elaeagnaceae. L.: Nauka, 1988; 92–3.
  3. Flora SSSR. Tom XVI. Pod red. akad. V.L. Komarova i B.K. Shishkina. M.-L.: Izdatel`stvo AN SSSR, 1950; 648.
  4. Gosudarstvennaya farmakopeya SSSR, HI izd., vyp. 2. M.: Medicina,1990; 398.
  5. Evropeyskaya farmakopeya, 7 izd. Toma 1, 2 (na russkom yazyke). Strasburg, 2011; 1812.
  6. Gosudarstvennaya farmakopeya RF HSh izd. [E`lektronnyy resurs]. Rezhim dostupa: http://www.rosminzdrav.ru/ministry/61/11materialy-po-deyatelnosti-deparatamtnta/stranitsa-856/spisok-obschih-farmakopeynyh-statey
  7. Strelyaeva A.V. i dr. Sravnitel`noe izuchenie fiziko-himicheskih svoystv i komponentnogo sostava petroleuma iz nefti razlichnyh mestorozhdeniy. Farmaciya, 2011; 8: 22–5.
  8. Shheglova T.A., Kurilov D.V., Strelyaeva A.V. Izuchenie himicheskogo sostava i antioksidantnoy aktivnosti matrichnoy nastoyki iz list`ev shalfeya lekarstvennogo. Farmaciya, 2012; 3: 27–30.