EVOLUTION OF PHARMACOPOEIAL REQUIREMENTS FOR SUPPOSITORY DOSAGE FORM

DOI: https://doi.org/10.29296/25419218-2018-03-01
Issue: 
3
Year: 
2018

I.V. Gammel(1), N.V. Pyatigorskaya(2), I.P. Rudakova(2) 1-Volga Research Medical University; 10/1, Minin and Pozharsky Sq., Nizhny Novgorod 603950, Russian Federation 2-I.M. Sechenov First Moscow State Medical University (Sechenov University); 4-2, Bolshaya Pirogovskaya St., Moscow 119991, Russian Federation

Suppositories are a common dosage form in Russia. The correct choice of the type of suppositories and the routes of their administration contribute to the high therapeutic efficacy of a drug. The investigators comparatively analyzed the requirements contained in different editions of the Russian State Pharmacopoeia for a suppository dosage form in the indices: its types and routes of administration, shape and mass. Outdated terms and shapes of suppositories were revealed. There was a duality when referring suppositories to as soft or solid dosage forms. The suppository dosage form has evolved over the course of a century, so the requirements for it have changed in new editions of the State Pharmacopoeia. The description of the types of suppositories and the routes of their administration, and the requirements for the shape and mass of their dosage form have been specified and updated in content in accordance with the level of pharmaceutical industry in our country.

Keywords: 
suppository dosage form
rectal suppositories
vaginal suppositories
sticks
State Pharmacopoeia
pharmacopoeial requirements

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