INVESTIGATION OF THE LARVICIDAL ACTIVITY OF HETARYL AMMONIUM DERIVATIVES

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DOI: https://doi.org/None
Issue: 
4
Year: 
2017

K.V. Lipatnikov; F.V. Sobin, PhD; Professor N.A. Pulina, PhD, I.P. Rudakova, MD Perm State Pharmaceutical Academy; 2, Polevaya St., Perm 614990, Russian Federation

ntroduction. The intensive use of insecticides leads to the development of insect resistance and to other negative consequences. Therefore it is necessary to search for new effective and safe pesticides, including larvicides. Thiophene derivatives have a marked insecticidal effect. Objective: to investigate larvicidal effects in a series of new 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates of hetaryl ammonium. Material and methods. The object of the investigation included 11 new synthesized hetaryl ammonium derivatives. Their acute toxicity was established in outbred albino mice. The larvicidal activity of the compounds was determined using Chironomidae mosquito larvae of age stages II-IV. Results. The heterocyclic moiety in the molecule was found to have a significant impact on the manifestation of larvicidal activity. The least pronounced effect was shown by the compounds containing pyridyl fragments. Incorporation of a 5-R-1,3,4-thiadiazole fragment into the structure of target products caused a substantial increase in larvicidal activity to the level of activity of a comparison drug. The safety profile of the most active derivatives was superior to that of the comparison drugs. Conclusion. New low-toxic compounds, such as derivatives of 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates of hetaryl ammonium, were identified, which exhibit larvicidal activity identical to that in the comparison drugs.
Keywords: 
larvicidal activity
2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates of hetaryl ammonium
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