PROCEDURES FOR IMPROVING THE SOLUBILITY OF POORLY WATER-SOLUBLE PHARMACEUTICAL SUBSTANCES

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DOI: https://doi.org/None
Issue: 
6
Year: 
2017

E.V. Blynskaya (1), PhD; D.V. Yudina (1); Professor K.V. Alekseev (2), PhD; A.I. Marakhova (3), PhD 1-V.V. Zakusov Research Institute of Pharmacology; 8, Baltiyskaya St., Moscow 125315, Russian Federation; 2-Moscow Medical University «REAVIZ»; 2, Krasnobogatyrskaya St., Build. 2, Moscow 107564, Russian Federation; 3-Peoples’ Friendship University of Russia; 6, Miklukho-Maklai St., Moscow 117198, Russian Federation

Drug bioavailability is determined by the physicochemical properties of a pharmaceutical substance (PS) and the technological properties of a selected formulation. At present, poorly water-soluble substances are as high as 40% of synthesized PSs, which creates certain difficulties for the design of formulations. The paper considers 5 major pharmaceutical factors affecting the solubility of PSs, which can be attributed to one of 3 main areas: modification of the physical and chemical characteristics of PS, use of excipients, and that of techniques that can enhance PS solubility.
Keywords: 
pharmaceutical substance
solubility
pharmaceutical factors
solid dispersion systems
self-emulsifying systems
References: 
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