DISPERSION ANALYSIS AND CHOICE OF EXCIPIENTS WHEN DESIGNING THE COMPOSITION TABLETS WITH CEREBROVASCULAR ACTIVITY

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DOI: https://doi.org/None
Issue: 
2
Year: 
2015

E.V. Blynskaya, PhD; A.S. Mikheeva; Professor K.V. Alekseev, PhD V.V. Zakusov Research Institute of Pharmacology; 8, Baltiyskaya St. Moscow 125315

The V.V. Zakusov Research Institute of Pharmacology synthesized the original substance of kemantan (5-hydroxyadamantane-2-on). According to the Health Development Program 2020, kemantan has a proven anti-ischemic activity and increases the blood supply to the brain in transient global ischemia. A mathematical planning method was used to investigate the choice of excipients when designing the composition of kemantan tablets. Analysis showed that the amount of an antifriction substance primarily affected the quality of the tablets; it was also found to be related to the type and quantity of a disintegrant.
Keywords: 
kemantan
tablets
excipients
mathematical planning
Fisher’s test
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