USE OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS TO INCREASE THE SOLUBILITY AND BIOAVAILABILITY OF A SUBSTANCE

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DOI: https://doi.org/None
Issue: 
4
Year: 
2015

Professor K.V. Alekseev, PhD; K.G. Turchinskaya; E.V. Blynskaya, PhD; A.I. Marakhova, PhD V.V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences; 8, Baltiyskaya St. Moscow 125315

To achieve the desirable concentration of a drug in systemic circulation is one of the most important parameters for its therapeutic efficacy and bioavailability. A self-microemulsifying drug delivery system (SMEDDS) has recently been the most promising technology for these purposes. Whether SMEDDS might be used to increase the solubility and bioavailability of compound GB-115 was investigated. The solubility of the compound was determined in different groups of excipients; pseudoternary phase diagrams were constructed; the thermodynamic stability of the model compositions of SMEDDS for GB-115 and the particle size distribution of obtained microemulsions were studied. Experiments showed the high potential of SMEDDS as an alternative to conventional methods for increasing the bioavailability of a drug substance.
Keywords: 
self-microemulsifying drug delivery system
microemulsions
GB-115
bioavailability
pseudoternary phase diagrams
References: 
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