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IMPACT OF STORAGE CONDITIONS ON THE EFFICACY AND QUALITY OF MEADOWSWEET (FILIPENDULA ULMARIA L.) FLOWERS

DOI: https://doi.org/None
Issue: 
6
Year: 
2015

D.V. Moiseev (1), PhD; Professor G.P. Yakovlev (2), PhD 1 -Vitebsk State Medical University; 27, Frunze Pr., Vitebsk 210023, Republic of Belarus 2 -Saint Petersburg State Chemopharmaceutical Academy; 14, Prof. Popov St., Saint Petersburg 197376

The paper considers new methodical approaches to investigating the impact of storage conditions of medicinal plant raw material on its quality. It proposes to study the chemical and pharmacological activity changes occurring in the raw material under storage conditions at higher temperature (up to 60°C) and moisture (up to 25%). Long-term (3-year) storage of meadowsweet (Filipendula ulmaria L.) flowers in the nonhermetic package was established to cause a decrease in flavonoid concentrations by 9.6% at 20°C and by 58% at 25% moisture. Their shortterm (68-day) storage in the non-hermetic package at 60°C reduced flavonoids concentrations by 23.2% and by 94% at 25% moisture. Their antioxidant activity was virtually unchanged when the raw material was stored under the examined conditions. In vitro studies first detected the ability of meadowsweet flowers to inhibit the hyperproduction of the cytokine transforming growth factor beta (TGF-β) with activated tumor cells, determining anti-inflammatory and immunosuppressive effects. Higher storage temperature promoted the lower anti-inflammatory activity of meadowsweet flowers.

Keywords: 
meadowsweet (Filipendula ulmaria L.)
high-performance liquid chromatography
flavonoids
storage
accelerated tests

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