VIRTUAL SCREENING IN A SEARCH FOR THE BIOLOGICAL ACTIVITY OF NOVEL DERIVATIVES OF ARYLBENZAMIDINES
DOI: https://doi.org/None
Issue:
8
Year:
2015
PASS and FlexX docking computer programs were used to isolate N’-(4-nitrophenyl)benzamidine, a low toxic and highly effective bezamidine derivative with broad-spectrum biological activity, from a number of synthetized amidines. The anticoagulant, antibacterial, anti-inflammatory, and analgesic activities predicted by the programs were confirmed by animal experiments.
Keywords:
N-arylbenzamidines. PASS program
FlexX docking
acute toxicity
biological activity
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