CATALYSTS FOR THE SYNTHESIS OF AMINES, THE INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF PHARMACEUTICAL SUBSTANCES

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DOI: https://doi.org/None
Issue: 
2
Year: 
2016

E.L. Kuzmicheva, PhD; Professor N.V. Pyatigorskaya, PhD; Professor E.A. Sapozhnikova, PhD I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991

Amines are one of the most important intermediate products in the manufacture of pharmaceutical preparations, dyes, polymers, and biologically active substances. The main method for their manufacture is the catalytic reduction of respective nitro compounds. The paper gives the results of an investigation of the activity of different catalysts, mainly oxide and metallic ones, on hydration of aliphatic nitro compounds. The process using palladium catalysts is most promising. The development a technology to obtain palladium catalysts can create pure technologies and improve the quality of the product.
Keywords: 
hydration
palladium and nickel catalysts
nitro compounds
amines
activity of catalysts
composition of catalysts
advantages and disadvantages of catalysts
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