The Journal is included in Russian and International Library and Abstract Databases
Russain Science Index (Russia)
DOI Registration Agency (USA)
Scientific Indexing Services (USA)
CAS Source index (USA)
Web of Science Group (USA)

Possible use of phytoecdysteroids in dental practice


S.V. Darmogray, A.V. Guskov, D.A. Zimankov, N.S. Erofeeva, V.N. Darmogray Academician I.P. Pavlov Ryazan State Medical University, 9, Vysokovoltnaya St., Ryazan 390026, Russia

Herbal remedies used especially to treat and prevent dental and periodontal diseases are retrospectively analyzed. The authors show for this purpose the prospects for the use of phytoecdysteroids, such as insect molting and metamorphosis hormones and other arthropods (crayfishes, crabs, shrimps, krills, etc.), as well as those providing a wide spectrum of biological and pharmacological effects on warm-blooded organisms, not being hormones for them. As an illustration of the highly effective effect of ecdysteroids on the representatives of the animal world, the authors give a brief overview of some patents and discoveries, which are of fundamental importance for understanding the role of ecdysteroids and for designing drugs in medical and pharmaceutical practice. It is also shown that these substances are practically non-toxic and do not cause any adverse effects, even when they are used long, and that they can be of importance in the very urgent problem of import substitution in our time. It is stated that it is necessary to search for these substances in the representatives of the plant world and marine fauna. The paper analyzes the scientific works by the employees of the University and dental clinics of Ryazan and the Ryazan Region, as well as those of Moscow, on the effects of particularly ecdysteroids, as well as teas that contain plant species producing these compounds, for periodontal and dental diseases,. The plants included in the herbal teas in question are the sources of these substances and plant species of other families, the biologically active substances of which nuanced the action of the ecdysteroid-containing representatives of the Carvophyllacea family for the treatment of periodontitis and teeth.

ecdysterone-containing drugs
herbal teas
Caryophyllaceae Juss

  1. Phytoekdisteroidy (by ed.V.V. Volodin). Sankt-Peterburg: Nauka, 2003: 293 (in Russian)
  2. Baltaev U.A. Phytoecdysteroids: structure, sources and pathways of plant biosynthesis. Bioorganicheskaya khimiya. 2000; 26 (12): 892–925 (in Russian)
  3. Darmogray V.N., Petrov V.K., Ukhov Yu.M. Theoretical and experimental-clinical substantiation of the conceptual model of the mechanism of action of ecdysteroids. Biokhimiya na rubezhe XXI veka. Sbornik nauchykh trudov. Ryazan', 2000: 489–92 (in Russian)
  4. Darmograi V.N., Petrov V.K. Medicinal plants and their products in dentistry. Aktual'nye problemy v stomatologii. Sbornik nauchykh trudov. Ryazan', 1998; 250–3 (in Russian)
  5. Shchul'kin A.V. Study of the antihypoxic and antiischemic effect of phytoecdysterone. Rossiyskiy mediko-biologicheskiy vestnik. 2011; 3: 30–4 (in Russian)
  6. Darmogray V.N., Erofeeva N.S., Darmogray S.V. et al. Qualitative and quantitative determination of ecdysteroids and polyphenolic compounds of the herb with earflaps small-flowered (Otites parviflorus Grossh.) Uspekhi sovremennogo estestvoznaniya. 2015; 12: 21–5 (in Russian)
  7. Darmogray S.V., Filippova A.S., Erofeeva N.S. et al. Natural producers of steroid and polyphenolic compounds from plants of the genus Minuartia (Minuartia Loefl. ex L.) family of cloves (Caryophyllaceae Juss.). Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii. 2018; 21 (10): 54–7. DOI: 10.29296/25877313-2018-10-10 (in Russian)
  8. Darmogray S.V., Dubodelova G.V., Trunova O.A. et al. Pharmacognostic study of leathery adonis. Nauka molodykh. 2016; 4: 52–5. DOI:10.23888/HMJ2016452-55 (in Russian)
  9. Darmograi S.V., Filippova A.S. To the pharmacognostic study of the plant of the genus Yaskolka of the flora of central Russia. Rossiiskiy mediko-biologicheskiy vestnik. 2016; 24 (3): 126–32 (in Russian)
  10. Darmogray S.V. et al. Carpathian sunseed (Ixoca pusilla (Waldst. Et Kit.) Sojak) – as a source of important steroid and polyphenolic compounds. Nauka molodykh. 2016; 4: 56–9. DOI:10.23888/HMJ2016456-59 (in Russian)
  11. Mishurov V.P., Zainullin V.G., Ruban G.A. et al. Introduction of Serratula coronata L. in the European northeast. Syk-Tyvkar, 2008; 192 (in Russian)
  12. Timofeev N.P. Safflower Leuzea and Crowned Serpukha are the basis of new innovative products. Rynok BAD. 2013; 1 (32): 3 (in Russian)
  13. Erofeeva N.S., Filippova A.S., Darmogray S.V., Ponomarenko A.A. HPLC identification of some steroid and polyphenolic compounds of cornflower head (Jurinea cianoides (L.) RCHB.). Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii. 2018; 21 (12): 27–31. DOI:10.29296/25877313-2018-12-04 (in Russian)
  14. Kuryakina N.V., Peshkov V.А., Darmogray V.N. Clinical results of the use of filling phytomaterial for root canals in the treatment of pulpitis. Materialy XI Mezhdunarodnogo simpoziuma «Netraditsionnoye rasteniyevodstvo. Eniologiya. Ekologiya i zdorov'ye». Simferopol', 2002: 716–9 (in Russian)
  15. Aref'eva O.V., Kuryakina N.V., Darmogray V.N. For the treatment of deep dental caries with an ecdysteroid agent. Informatsionnyy listok Ryazanskogo Mezhotraslevogo TsNTI. 2000; 61–127: 4 (in Russian)
  16. Gus'kov A.V., Zimankov D.A., Anvarkhonova D.B. et al. Inflammatory reactions of the pulp and periodontium when using fixed structures with a large volume of odontopreparation. Klinicheskaya stomatologiya. 2018; 4: 56–9 (in Russian)