Nanodiamond as an agent for delivery of cytostatics

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DOI: https://doi.org/10.29296/25419218-2021-07-02
Issue: 
7
Year: 
2021

V.V. Andreeva, M.A. Maryasov, N.P. Romashov, O.E. Nasakin I.N. Ulyanov Chuvash State University, 15, Moskovsky Prosp., Cheboksary 428015, Russian Federation

Introduction. To deliver a drug directly to the biological target is one of the main problems with chemotherapy. Innovative nanocarrier-based drugs can solve this problem. Carbon nanostructures are one of the main contenders for the role of ideal carriers for drug delivery systems. Nanodiamond has the least toxic effect among the carbon nanostructures. Objective: to immobilize biologically active polycarbonitriles on the surface of a detonation nanodiamond (DND) to obtain candidates in the substance with antiproliferative activity. Material and methods. The objects of the investigation were synthesized organic cyano compounds. The latter were placed on the surface of DNDs, by using the mechanochemical technique. Cytotoxicity was verified by a proliferative MTT assay. Results. The adsorption of carbonitrile compounds of Class 6 on the surface of DND was carried out and the antiproliferative activity of the three obtained candidates for pharmaceutical substances was investigated. Conclusion. The authors have developed a method that can obtain nanodiamond-based nitrile-containing substances that can be used in the design of medicines.
Keywords: 
nanodiamond
detonation synthesis
organic cyano compounds
antiproliferative activity
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