Mineral Carriers for Oral Drug Delivery

DOI: https://doi.org/10.29296/25419218-2022-01-02
Issue: 
1
Year: 
2022

A.V. Bondarev(1), E.T. Zhilyakova(2), N.V. Avtina(2) 1-Regional State Budgetary Healthcare Institution «Shebekino Central District Hospital», st. Lenin, 46, Shebekino, 309290, Russian Federation; 2-Belgorod State National Research University, st. Victory, 85, Belgorod, 308015, Russia

Introduction. Currently, the development of drug delivery systems is one of the priorities of pharmaceutical technology. Objective: The purpose of the work is to review the scientific and technical literature concerning the possibility of using mineral carriers for oral delivery of medicinal substances. Material and methods: To achieve this goal, it was necessary to review the use of mineral carriers for oral drug delivery, as well as the systematization and classification of mineral carriers for the oral drug delivery. Electronic resources such as eLibrary, CyberLeninka, PubMed were used as research materials. Research methods are analysis and generalization. The study covered the scientific literature for the period from 2002 to the present. Results. It has been established that mineral carriers can be used for oral delivery of the following drug groups: nonsteroidal anti-inflammatory drugs, antibiotics, hypotensive, antitumor, and antipsychotic drugs. The systematization and classification of mineral carriers for oral delivery of medicinal substances has been carried out. It was established that currently five potential groups of medical clays should be considered as mineral carriers: palygorskite (attapulgite), kaolin, smectite, zeolite, and silicon dioxide. Conclusion. Now, zeolites based on the mineral clinoptilolite are at the stage of study and are promising mineral raw materials for obtaining carriers of medicinal substances. Different types of pores of mineral carriers allow them to adsorb drugs and release them in a more pharmacologically active form. Porous mineral carriers based on montmorillonite clay are used to improve the oral bioavailability of poorly water-soluble medicinal substances by increasing their solubility.
Keywords: 
mineral carrier
medical clay
oral delivery system
pores
sorption
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