Quantum-chemical calculation as a method of theoretical prediction of the physico-chemical interaction of intranasal gel components

DOI: https://doi.org/10.29296/25419218-2022-08-05
Issue: 
8
Year: 
2022

E.V. Kovtun(1), L.V. Pogrebnyak(1), Е.F. Stepanova(1), А.V. Pogrebnyak(1), D.О. Bokov(2), Monеb M.Y.Dadou(1),
1-Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532, Russian Federation;
2-A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation

Introduction. An important area of pharmaceutical research is the creation of new, as well as the improvement of existing available dosage forms, using already known medicinal substances as active substances. Currently, the issues of developing drugs that activate the integrative properties and functions of the brain, as well as increase the body's resistance to aggressive influences, are relevant. A group of drugs that regulate such conditions are nootropics, namely piracetam and its analogues. The advantages of nasal dosage forms for realizing this are obvious. This is both high bioavailability and the possibility of systemic action of medicinal substances. The speed of development of the effect, as a result of the active absorption of medicinal substances that are cleaved in the gastrointestinal tract. Objectives: selection and theoretical justification of an intranasal dosage form containing piracetam as an active ingredient and several different excipients. Material and methods. When creating an intranasal dosage form with a nootropic effect, various research methods were used: technological, biopharmaceutical. And also, methods of molecular mechanics and quantum chemistry. Results. Theoretical and experimental studies on the choice of excipients for intranasal dosage form have been carried out. Conclusion. The conducted studies prove the feasibility of developing a dosage form technology – an intranasal gel with piracetam, which has nootropic activity.
Keywords: 
intranasal delivery
piracetam
gel
chitosan
carbopol
computer molecular modeling.
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