CANDIDA BIOFILM MODELING: PAST AND PRESENT

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DOI: https://doi.org/10.29296/25419218-2019-03-03
Issue: 
3
Year: 
2019

N.P. Sachivkina(1), E.M. Lenchenko(2), R.T. Mannapova(3), А.А. Strizhakov(1), E.V. Romanova(1), D.M. Lukina(1) 1-Peoples’ Friendship University of Russia, 6, Miklukho-Maklai St., Moscow 117189, Russian Federation;2-Moscow State University of Food Production, 11, Volokolamskoe Sh., Moscow 125080, Russian Federation;3-K.A.Timiryazev Russian Agrarian University, 49, Timiryazevskaya St., Moscow 127550, Russian Federation

Mycoses are often associated with biofilms that are microbial communities encapsulated in a polysaccharide-rich extracellular matrix. Species of yeast-like fungi belonging to the genus Candida are the most common pathogens that cause superficial, deep, and systemic mycoses. Microorganisms that make up the biofilm have recently demonstrated decreased susceptibility to most therapeutic drugs, which contributes to the long-term persistence of infection. At the moment, there is a new branch of preventive and therapeutic medicine, which needs pharmaceuticals to be designed to prevent the formation of biofilms or the destruction of the already formed ones. Recent technological advances have contributed to the elaboration of new approaches to investigating the formation of biofilms and their models and to accumulating extensive knowledge about the influence of different variables on biofilm formation, morphology, and architectonics. There is information on current methods for modeling Candida biofilms and on their advantages or disadvantages in their structure and mechanisms.
Keywords: 
Candida
Candida spp.
biofilms
matrix
modeling
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