DESIGN AND STANDARDIZATION OF THE COMPOSITION OF SUPPOSITORIES CONTAINING ANTIVIRAL COMPONENTS

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DOI: https://doi.org/10.29296/25419218-2019-03-05
Issue: 
3
Year: 
2019

A.Yu. Saenko(1), E.F. Stepanova(1), D.S. Lazaryan(1), A.Yu. Petrov(2), I.Ya. Kul(1) 1-Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University, 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation; 2-Ural State Medical Academy; 3, Repin St., Yekaterinburg 620028, Russian Federation

Introduction. The antiviral drug Acyclovir is widely used in medical practice. The new antiviral drug Ryamilovir has recently appeared on the Russian pharmaceutical market.Objective: to design suppositories containing 2 antiviral drugs: Acyclovir and Ryamilovir.Methods. The investigation used the following methods: thin layer chromatography (TLC), spectrophotometry, semipermeable membrane dialysis, and statistical processing of the results.Results. The composition of bases and excipients was selected: it is recommended to use cocoa butter and aerosil as a suppository base under pharmacy conditions and polyethylene oxide and glyciram under production-line conditions. Components were identified using TLC and quantified by spectrophotometry, which allows one to determine both components in one sample. Conclusion. The composition of the suppositories containing 2 antiviral drugs Acyclovir and Ryamilovir was designed. A procedure was proposed to identify components using TLC and quantitative spectrophotometric determination.
Keywords: 
suppositories
acyclovir
ryamilovir
spectrophotometry
thin layer chromatography
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