Biopharmaceutical studies of a combination gel containing CO2-extract and essential oil of Chinese magnolia vine (Schizandra chinensis) seeds

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DOI: https://doi.org/10.29296/25419218-2019-05-06
Issue: 
5
Year: 
2019

E.F. Stepanova(1), Yu.A. Morozova(1, 2), Z.D. Khadzhieva(1) 1-Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University, 11, Kalinin Pr., Pyatigorsk 357532, Russian Federation; 2-Kosta Levanovich Khetagurov North Ossetian State University, 44-46, Vatutin St., Vladikavkaz 362025, Russian Federation

Introduction. Chinese magnolia vine (Schizandra chinensis) is the most valuable type of medicinal plant materials, which can be used to design novel effective stimulants and adaptogens. Objective: to conduct in vitro biopharmaceutical studies on selecting the optimal composition of a combination gel containing supercritical carbon dioxide extract and essential oil of Chinese magnolia vine seeds. Material and methods. The investigation objects were Chinese magnolia vine seed essential oil extracted by steam distillation, followed by liquid-liquid extraction and supercritical carbon dioxide extraction from the oil cake remaining after distillation. The optimal composition of the gel was selected using dialysis through the biological membrane. The colloidal and thermal stability of the best composition, as well as its structural and mechanical properties were studied. Results. The highest degree of 72% release at hour 10 of the experiment was observed for the model composition with 2% essential oil; a further increase in its concentration is impractical. This composition has thermal and colloidal stabilities: delamination of the system and/or separation of oil phase droplets were not observed. The gel is able to alter its structure under mechanical action and to restore the previous structure after its cessation; it has thixotropic properties. Conclusion. The authors have proposed the optimal composition of the transdermal combination gel containing CO2 extract from oil cake and essential oil of Chinese magnolia vine seeds.
Keywords: 
Chinese magnolia vine
Schisandra chinensis (Turcz.) Baill.
seeds
transdermal gel
References: 
  1. Mikhailov V.G., Shalimov M.P., Aliev H.M., Nesteruk A.V. improving the means of psychophysiological correction for recovery of functional status after excessive physical activity in persons of hazardous occupations. Voenno-medicinskiy zhurnal, 2012; 333 (1): 70–1 (in Russian).
  2. Kupko E.N., Gusova B.A., Molchanov M.V., Semukhin A.M. analysis of pharmacological approaches to increase the physical performance of rescuers in emergency situations. Farmatciya i farmakologiya, 2014; 6 (7): 88–91 (in Russian).
  3. Shabanov P.D. Adaptogens and antihypoxants. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii, 2003; 2 (3): 50–81 (in Russian).
  4. Kosman V.M., Pozharitskaya O.N., Shikov A.N., Makarov V.G.. Lignans oil extract of seeds of Schisandra chinensis (Schisandra chinensis Turcz. (Bail.)). Himiya rastitel'nogo syr'ya, 2014; (4): 131–8 (in Russian).
  5. Kosman V. M., Karlina M. V., Pozharitskaya O. N., Shikov A. N., Makarov V.G., Vorob'ev V.V., Lapkina, G.J. The Pharmacokinetics of Schisandra chinensis lignans. Obzory
  6. po klinicheskoy farmakologii i lekarstvennoy terapii, 2015; 13 (4): 3–21 (in Russian).
  7. State register of medicines (Electronic resource). Access mode: http://grls.rosminzdrav.ru/grls.aspx (in Russian).
  8. Kasyanov G.I. Technique and technology of carbon dioxide use in sub – and supercritical state. Vestnik VGUIT, 2014; (1): 130–5 (in Russian).
  9. Bukeeva, A.B., Kudaibergenova S.Zh. Review of current methods for the isolation of bioactive compounds from plants. Vestnik ENU im. L.N. Gumileva, 2012; (2): 192–7 (in Russian).
  10. Makieva M.S., Morozov A.Yu., Voronkov AV., Stepanova E.F., Remezov I.P., Pozdnyakov D.I. Development of transdermal gel of oil of Schisandra chinensis and evaluation of the extent of its influence on the performance and the neurological status of animals in the experiment. Medicinskiy vestnik Severnogo Kavkaza, 2016; 11, (4): 532–6 (in Russian).
  11. Sidel'nikov V.N., Patrushev Yu.V., Sizov N.In. Petrenko T.V. Comparative analysis of the composition of pine oil, obtained by water-steam distillation and essential oil fraction of CO2-extract of Siberian fir legs. Himiya rastitel'nogo syr'ya, 2003; (1): 79–85 (in Russian).
  12. Morozov Yu.А., Makieva M.S., Morozova E.V., Eliseev E.G. The study of the rheological properties of the gel of Schisandra chinensis seed CO2-extract. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Medicina. Farmatciya, 2016; 35 (19/240): 169–75 (in Russian)