The study of the nootropic activity of a complex pharmaceutical substance of plant origin based on ginkgo biloba, hawthorn, valerian, melissa, motherwort tinctures

DOI: https://doi.org/10.29296/25419218-2022-03-08
Issue: 
3
Year: 
2022

A.I. Ovod, E.Yu. Kuznetsova
Kursk State Medical University; Karl Marx st., 3, Kursk, 305041, Russian Federation

Introduction. According to WHO, about 78 million children are born annually in the world with pathology of the central nervous system, which manifests itself in the first years of life with a delay in psycho-speech and motor development, up to dementia, which makes the development and study of nootropic remedies with a sedative effect relevant. Objective: to study the nootropic activity of the complex pharmaceutical substance of plant origin (CPSPO) based on ginkgo biloba, hawthorn, valerian, melissa, motherwort tinctures. Material and methods. The study of the nootropic activity of the CPSPO was carried out by the effect on learning in the method of a conditioned reflex with positive reinforcement, using a Y-shaped maze. Results. The data obtained indicate the presence of a reliable nootropic activity in the tested CPSPO, which is comparable to the reference preparation. Conclusion. The studied CPSPO based on ginkgo biloba, hawthorn, valerian, melissa, motherwort tinctures has a significant nootropic activity compared to the reference preparation.

Keywords: 
nootropics;
complex complex pharmaceutical substance of plant origin
tincture
sedatives

References: 
  1. Klitochenko G.V., Malyuzhinskaya N.V., Shcheglova O.M., Kasimovska O.N. The use of nootropic drugs in pediatrics. Medicinal Bulletin. 2017; 4 (68); v. 11: 15–9 (in Russian)
  2. Voronina T.A., Litvinova S.A. Pharmacological effects and clinical use of pantogam and pantogam active. J. of Neurology and Psychiatry. 2017; 8: 132–9 (in Russian)
  3. Fardieva R.M., Zalyalyutdinova L.N. The use of nootropics for intellectual disability in children. Modern problems of science and education. 2013; 2. [Electronic edition]. Access mode: https://science-education.ru/ru/article/view?id=8899 (date of access: 03/22/2022) (in Russian)
  4. Zhalsray A. Study of the neuroprotective properties of extracts from medicinal plants in models of diseases of the central nervous system: thesis… dr. bio. Sciences (14.03.06) / Zhalsray Aldarmaa. «Institute of Traditional Medicine and Technology of Mongolia». Tomsk, 2019; 312 (in Russian).
  5. Guidelines for pre-clinical study of medicinal products. Part 1. (by ed. A.N. Mironov). Moscow: Grief and K, 2012; 944 (in Russian)
  6. Imamaliev B.A., Fayzieva Z.T. Study of subacute toxicity (cumulation) of the liquid extract of Phytoallergoderm. Pharmacy. 2020; 69 (7): 52–6. https://doi.org/10.29296/25419218-2020-07-09 (in Russian).
  7. Imamaliev B.A. Investigation of the anti-allergic activity of the herbal remedy Phytoeczemaderm. Farmatsiya. 2021; 70 (2): 51–5. https://doi.org/10/29296/25419218-2021-02-08 (in Russian)
  8. The State Pharmacopoeia оf the Russian Federation, XIV-ed. [Electronic resource]. Access mode: http://femb.ru/feml (in Russian)