The study of gonadotropic action of the plant Ferula assa-foetida


R.S. Samedinov(1), A.N. Nabiev(1), S.Kh. Tulyaganov(2)
1-Tashkent Pharmaceutical Institute, Oybek 45 st., Tashkent, 100015, Uzbekistan;
2-“ABDU-S” Ltd. Rakat, 4/27 st., Tashkent, 100100, Uzbekistan

Introduction. Nowadays, in the arsenal of urologists there are special preparations of the gonadotrofic effect of a chemical nature existing, but preparations of plant origin will in many cases be more preferable for stimulation of spermatogenesis and sex steroid production. In this work, the gonadotropic effect of plant Fеrula assa-fоetida was revealed for the first time. It was proven that the drug action was not centrally stimulating. Objective: to study the gonadotropic action of plant Fеrula assa-fоetida. Material and methods. The work was carried out on 25 immature (four-month old) mongrel male rats weighing 70–90 grams. The rats were divided into 5 groups, 5 rats in each group. The first group was intact and received water in an appropriate volume. The second group received Menotrophin at a dose of 7 units per body weight. The third group received Menotrophin at a dose of 14 units per body weight. The fourth group received plant Fеrula assa-fоetida at a dose of 100 mg/kg orally for 7 days before the experiment + 28 units per body weight of Menotrophin. The fifth group – control, this group of animals was administered plant Fеrula assa-fоetida, orally at a dose of 100 mg/kg for 7 days before the experiment. Results. The tests carried out in the experiment showed that plant Fеrula assa-fоetida in the dose of 100 mg/kg did not have any centrally stimulating gonadotropic action in comparison with the intact group. Conclusion. Thus, due to the absence of central gonadotropic action of the plant Fеrula assa-fоetida will not affect the synthesis of two hormones of the anterior pituitary lobe: luteinizing and follicle stimulating hormones, which in turn will prevent such conditions as premature menopause, ovarian hypofunction, precocious puberty, hyperfunction or pituitary tumors.

reproductive system
gonadotropic action

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