CATALYTIC SYNTHESIS OF AMINO COMPOUNDS, INTERMEDIATES FOR THE SYNTHESIS OF PHARMACEUTICAL SUBSTANCES

One of the expected outcomes of the Pharma-2020 strategy is to organize the production of substances on the territory of the Russian Federation. The paper gives information on the design and use of catalysts for the synthesis of amino compounds and the results of investigations of the activity of various catalysts, mostly oxide and metal ones, on hydrogenation of aliphatic nitro compounds. It shows the advantage of palladium-based catalysts over nickel skeleton catalysts. The development of their production technology allows one to create an environmentally pure technology, to improve the quality of the prepared product, and to standardize the catalyst. Palladium catalysts can be used repeatedly (over 50 times), which will be able to create a continuous hydrogenation process on granulated catalysts at a later date. The designed palladium catalysts are used in the production of folic acid (hydrogenation of p-nitrobenzoyl-L-glutamic acid and 2,4-diamino-5-isonitroso-6-oxopyrimidine), theophylline (1,3-dimethyl-4,5-aminouracil), theobromine (3-methyl-4,5-aminouracil), anesthesin, droperidol, etc.