THE STRUCTURAL AND MECHANICAL PROPERTIES OF A PROTECTIVE FILM WITH AN ALOE LIQUID EXTRACT AND ACTOVEGIN

DOI: https://doi.org/10.29296/25419218-2018-06-06
Issue: 
6
Year: 
2018

V.M. Kishchenko, E.F. Stepanova, V.V. Vernikovsky, I.M. Privalov Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University, 11, Kalinin Pr., Pyatigorsk, Stavropol Territory 357532, Russian Federation

Introduction. Currently, treatment products, such as films, have substantially increased in popularity in various fields of medicine and cosmetology. Despite the functional diversity of the considered dosage form, the basis for all films is polymers of different origin. The films are most frequently made on the basis of cellulose and its derivatives. The authors have designed dermatological films based on hydroxypropyl methyl cellulose with an aloe liquid extract and actovegin. Objective: to investigate the rheological characteristics when selecting the optimal composition of excipients to design a dermatological film containing a natural composition with an aloe liquid extract and actovegin Material and methods. A Fungilab PREMIUM rotational viscometer with a TR 9 spindle and a small sample adapter was used in the investigation. Results. Statistical data processing could have the dynamic viscosity η (Pas) and the shear stress τ (Pa), as well as the shear rate γ (sec-1). These indicators were used to construct the flow curve and viscosity one of experimental samples and their complex analysis was carried out. Conclusion. The obtained flow and viscosity curves could identify film mass samples for further investigations.

Keywords: 
films
structural and mechanical properties
fluidity
rheology
polymers

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