INVESTIGATION OF THE PHENOLIC COMPOUNDS OF HERBAL TEAS IMPROVING COGNITIVE AND MNESTIC FUNCTIONS

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DOI: https://doi.org/None
Issue: 
4
Year: 
2017

D.A. Trashchenkova (1); T.Yu. Kovaleva (1), PhD; Professor I.A. Samylina (1), PhD; I.V. Shilova (2), PhD; Professor N.I. Suslov (2), MD 1-I.M. Sechenov First Moscow State Medical University; 2, B. Pirogovskaya St., Build. 4, Moscow 119991, Russian Federation 2-E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; 3, Lenin Pr., Tomsk 634028, Russian Federation

Introduction. Cognitive and mnestic disorders occur more and more frequently and affect all age groups, including children. Healing herbal teas are effective and safe agents for the prevention and treatment of these disorders. The authors have designed two compositions of herbal teas from medicinal plant raw materials, which have a neurotropic effect. The herbal teas included meadowsweet (Filipendula ulmaria) herb, leather bergenia (Bergenia crassifolia) leaves, and bilberry (Vaccinium myrtillus) shoots. Objective: to comparatively analyze a set of phenolic compounds in the 2 herbal teas in order to provide a rationale for approaches to standardizing the pharmacopoeial substance of plant origin and for the choice of its dosage form. Material and methods. The object of the investigation included 2 herbal teas prepared in a laboratory setting. The qualitative composition of biologically active substances (BAS) in the herbal teas was investigated by thin-layer chromatography. The levels of tannins, flavonoids, and extractive substances in the teas of the herbs and their decoctions were determined by the methods described in the State Pharmacopoeia of the Russian Federation, XIII edition. Results. There was evidence that rutin, tannin, and gallic acid were present in the herbal teas. Quantitative analysis of BAS revealed a significant content in the herbal teas containing tannins and flavonoids and also confirmed the benefits of herbal tea two. Large amounts of flavonoids and tannins converted to the decoctions of tested herbal teas. Conclusion. The investigation of herbal teas and aqueous extracts allowed determination of the optimal composition of a tea. The findings correlate with the results of preclinical studies and provide a basis for a deeper study of herbal tea two.
Keywords: 
phenolic compounds
flavonoids
tannins
cognitive-mnestic disorders
neurotropic activity
thin layer chromatography
References: 
  1. Evtushenko S.K., Morozova T.M., Shestova E.P. et al. Cognitive disorders in children: neurophysiologic estimation and correction. Mezhdunarodnyj nevrologicheskij zhurnal, 2010; 1 (31). [Electronic resource]. Mode of access: http://www.mif-ua.com/archive/article/11828 (in Russian).
  2. Levin O.S. Diagnosis and treatment of moderate cognitive disorders in the elderly. Zhurnal nevrologii i psihiatrii, 2006; 8: 42-49. [Electronic resource]. Mode of access: http://medi.ru/doc/f421929.htm (in Russian).
  3. Drobizhev M. Ju., Makuh E. A., Dzantieva A. I. Cognitive disorders in medicine. Zhurnal Lechaschi Vrach , 2007; 08. [Electronic resource]. Mode of access: http://www.lvrach.ru/2007/08/4716376/ (in Russian).
  4. Preobrazhenskaja I.S. Cognitive impairments and sleep disorders. Jeffektivnaja farmakoterapija. Nevrologija, 2015; 3(23). [Electronic resource]. Mode of access: http://umedp.ru/articles/kognitivnye_narusheniya_i_rasstroystva_sna.html (in Russian).
  5. Zaharov V.V. Cognitive disorders in neurological practice. Trudnyj pacient, 2005; 3 (5): 4-9. [Electronic resource]. Mode of access: http://t-pacient.ru/articles/6078/ (in Russian).
  6. Zaharov V.V. Evolution of cognitive deficit: mild and moderate cognitive impairments. Nevrologija, nejropsihiatrija, psihosomatika, 2012; 2: 16–21 (in Russian).
  7. Burchinskij S.G., Demchenko E.V. Innovations in pharmacotherapy strategy on the early stages of cognitive impairment. Mezhdunarodnyj nevrologicheskij zhurnal, 2016; 6 (84): 85–90 (in Russian).
  8. Shilova I.V., Suslov N.I., Otmahov V.I. et al. Chemical-pharmacological study of herbal preparations improving cognitive-mnestic functions. Himiko-farmacevticheskij zhurnal, 2016; 50 (10): 27–32 (in Russian).
  9. Shilova I.V., Samylina I.A., Suslov N.I., Kovaleva T.Yu. Anxiolytic herbal tea. Patent RF 2565452 from 23.10.2014 (in Russian).
  10. Krasnov E.A., Avdeeva E.Ju. The chemical composition of the Genus Filipendula. Himija rastitel'nogo syr'ja, 2012; 4: 5–12 (in Russian).
  11. Kruglova M.Ju., Kruglov D.S., Fursa N.S. Analysis of phenol complex of two species of meadowsweet (filipendula). Farmatsiya, 2012; 7: 21–3 (in Russian).
  12. Kurkin V.A., Rjazanova T.K. Quantitative determination of the total flavonoid content in Bilberry Offshoots. Himiko-farmacevticheskij zhurnal, 2013; 47 (4): 34–7 (in Russian).
  13. Kurkin V.A., Rjazanova T.K., Petruhina I.K. Vaccinium myrtillus: modern approaches to the standardization of raw material and the creation of medicines. Samara: SamGMU, 2014; 29–51 (in Russian).
  14. Moiseev D.V. Validation of assay Arbutine in leaves of Bergenia by HPLC. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Serija: Medicina. Farmacija., 2016; 34. 12 (233): 143–9 (in Russian).
  15. Renáta Árok, Krisztina Végh, Ágnes Alberti, Ágnes Kéry. Phytochemical comparison and analysis of Bergenia species. Eur. Chem. Bull., 2012; 1(1-2): 31–4
  16. Shilova I.V., Suslov N. I., Samylina I. A. The chemical composition and nootropic activity of plants in Siberia. Tomsk: izdatel’stvo Tomskogo gosudarstvennogo universiteta, 2010; 236 (in Russian).
  17. Shilova I.V., Samylina I.A., Suslov N.I., Kovaleva T.Ju., Baeva V.M. Nootropic herbal tea. Patent RF 2578453 from 23.04.2015 (in Russian).
  18. Shilova I.V. The chemical composition of plants in Siberia and the development of nootropic products based on them. PhD investigation. Pjatigorsk, 2011; 465 (in Russian).
  19. Fedoseeva L. M. Experimentally-theoretical justification of Siberian flora Bergenia crassifolia using as the medicinal raw material. PhD investigation. Perm’, 2001; 337 (in Russian).
  20. State Pharmacopoeia of RF, XIII edition [Electronic resource]. Mode of access: http://www.femb.ru/feml (in Russian).