ANTIDEPRESSANT ACTIVITY OF REDHAW HAWTHORN (CRATAEGUS SANGUINEA) EXTRACTS

DOI: https://doi.org/None
Issue: 
4
Year: 
2017

T.V. Morozova, Professor V.A. Kurkin, PhD; E.N. Zaitseva, PhD; Professor A.V. Dubishchev, PhD; A.V. Kurkina, PhD; O.E. Pravdivtseva, PhD; N.A. Volkova Samara State Medical University; 89, Chapaevskaya St., Samara 443099, Russian Federation

Introduction. The leaves and shoots of redhaw hawthorn (Crataegus sanguinea) are promising raw materials to prepare new effective Russian medicines. Objective: to comparatively investigate the antidepressant activity of liquid extracts of redhaw hawthorn flowers, shoots, and leaves. Material and methods. The objects of the investigation included liquid extracts of redhaw hawthorn leaves, flowers, and shoots. Outbred albino rats were used to study the antidepressant activity of the liquid extracts by the behavioral despair test and their acute toxicity was determined. Results. All test liquid redhaw hawthorn extracts increased animal locomotor activity: the extract of its leaves did it slightly; that extracts of shoots and flowers did by 68 and 201%, respectively. The liquid extracts of hawthorn flowers and shoots had the pronounced antidepressant activity comparable with that of amitriptyline. Despite the high content of flavonoids, the extract of hawthorn leaves did not show significant antidepressant activity. All of the test liquid extracts belong to class IV toxicity. Conclusion. The liquid extracts of redhaw hawthorn flowers and shoots were found to have the antidepressant activity comparable with that of amitriptyline.

Keywords: 
redhaw hawthorn
Crataegus sanguinea Pall.
flowers
leaves
shoots
fruits
flavonoids
hyperoside
antidepressant activity
acute toxicity

References: 
  1. State Pharmacopoeia of the USSR, XI-th ed., Vol. 2. Moscow: Medicine, 1990; 400 (in Russian).
  2. Kurkin V.A. Pharmacognosy. Samara: Ofort; SamGMU, 2016; 1279 (in Russian).
  3. Kurkin V.A. Elements of phytotherapy. Samara: Ofort; SamGMU 2009; 963 (in Russian).
  4. Muraveva D.A., Samylina I.A.,Yakovlev G.P. Pharmacognosy. Moscow: Medicine, 2002; 656 (in Russian).
  5. Kurkin V.A., Kurkina A.V., Zaitceva E.N., Dubishchev A.V., Pravdivtseva O.E., Morozova T.V. Diuretic and antidepressant activity of soft extract hawthorn blood-red. Byulleten' sibirskoy mediciny, 2015; 14 (3): 18–22 (in Russian).
  6. Morozova T.V., Kurkina A.V., Pravdivtseva O.E., Dubishchev A.V. Pharmacognostic and pharmacological study of the Hawthorn raw material. Proceedings of the Samara Scientific Center of the Russian Academy of Sciences, 2015; 17 (5): 959–63 (in Russian).
  7. Chernikova V.V. Early diagnosis of cardiovascular disorders in patients with dystrophic myotonia. Aspirantskiy vestnik Povolzh'ya, 2014; 1-2: 75–7 (in Russian).
  8. Trofimova S.V., Khasanova S.R., Kudashkina N.V. Study of anti-arrhythmic activity of the leaves of Crataegus sanguinea (Rosaceae). Medicinskij vestnik Bashkortostana, 2011; 6 (2): 299–302 (in Russian).
  9. Hasanova S.R., Trofimova S.V., Kudashkina N.V. Determination of flavonoid composition of the leaves of hawthorn blood-red of the flora of Belarus HPLC. Modern medicine and pharmaceutics: analysis and perspectives of development. Materials VIII of the International scientific-practical conference. Moscow: Sputnik, 2013; 36 (in Russian).
  10. Plant resources of the USSR: Flowering plants, chemical composition, the use of; Families Hydrangeaceae – Haloragaceae. Leningrad: Nauka, 1987; 34–42 (in Russian).
  11. European Pharmacopoeia. 6th ed. Rockville: United States Pharmacopoeial Convention, Inc., 2008.
  12. Kurkina A.V. Flavonoids of pharmacopoeia plants. Samara: Ofort, SamGMU, 2012; 290 (in Russian).
  13. Khabriev R.U. Manual on experimental (preclinical) study of new pharmacological substances (ed. Habrieva R.U.) Moscow: Medicine, 2005; 832 (in Russian).