The Journal is included in Russian and International Library and Abstract Databases
Russain Science Index (Russia)
DOI Registration Agency (USA)
Scientific Indexing Services (USA)
CAS Source index (USA)
Web of Science Group (USA)



I.I. Terninko (1), PhD; I.O. Suina (1); E.V. Burtseva (2), PhD ; M.V. Ogloblina (3), PhD 1-Saint Petersburg State Chemopharmaceutical Academy; 14 A, Professor Popov St., Saint Petersburg 197376, Russian Federation; 2-Lugansk State Medical University; 1, Lugansk Defense Quarter, Lugansk 91045; 3-Pilip Orlik International Classical University; 2, Kotelnaya St., Nikolaev 54003, Ukraine

The paper generalizes and systematizes the data available in the literature on pharmacognostic study (botanical characteristics, geographical distribution, and chemical composition) and ethnopharmacological features of using the plants of the genus Aristolochia in folk medicine in the world. The main components are shown to be aristolochic acid, the alkaloid aristolochine, and essential oil. Attention is drawn to the specific toxic action of aristolochic acid that has a negative effect on the kidney. The authors consider prospects for comprehensively studying and elaborating approaches to standardizing the raw material of European birthwort distributed on the territory of the Russian Federation. A deeper study of the raw material of European birthwort will be able to expand the range of raw material sources for domestic phytopreparations.

European birthwort
Aristolochia сlematitis L.
chemical composition
aristolochic acid

  1. Willer F., Silva Jr., Samyra G.Cecílio, Magalhães Cintia L.B. Combination of extracts from Aristolochia cymbifera with streptomycin as a potential antibacterial drug. Springer Plus., 2013; 2: 90–7.
  2. Sidorenko V. Zloveshhaya liana ili Tayna nefropatii. Himiya i zhizn`, 2013; 10: 16–20. [SidorenkoV. Sinister liana or Mystery nephropathy. Khimiya i zhizn, 2013; 10: 16–20 (in Russian) ].
  3. Olabanji S.O., Omobuwajo O.R., Ceccato D., Adebajo A.C., Buoso M.C., and Moschini G. Accelerator-based analytical technique in the study of some anti-diabetic medicinal plants of Nigeria. Nucl. Instr and Meth. In., 2008; 266: 2387–90.
  4. Chen Y.Y., Chiang S.Y., Wu H.C., Kao S.T., Hsiang C.Y., Ho T.Y., Lin J.G. Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells. Acta Pharmacol., 2010; 31(2): 227–36.
  5. Doktor N. Gomeopatiya. Gomeopaticheskie monopreparaty. [E`lektronnyy resurs]. Rezhim dostupa: [Doktor. N. Homeopathy. Homeopathic monopreparations. [Electronic resource]. Access: (in Russian)]
  6. The Plant List: aristolochia // Aristolochia. Version 1.1[Electronic resource]. Access:
  7. Plantarium, opredelitel` rasteniy. [E`lektronnyy resurs]. Rezhim dostupa: [Plantarium, plant determinant.[Electronic resource]. Access: (in Russian)]
  8. Kuo P.-Ch.,Li Yu.-Ch., Wu T.-Sh. Chemical Constituents and Pharmacology of the Aristolochia species. Journal of Traditional and Complementary Medicine, 2011; 4: 249–66.
  9. Samsonova O.E., Belous V.N., Dudar Yu.A. Pharmacological characterization of Aristolochia clematitis L. growing in the Stavropol Region. Pharmaceutical Chemistry Journal, 2006; 4:199–201.
  10. Kuo Ch.-H., Lee Ch.-W., Lin Sh.-Ch. Rapid determination of aristolochic acids I and II in herbal products and biological samples by ultra-high-pressure liquid chromatography–tandem mass spectrometry. Talanta, 2010; 80:1672–80.
  11. Krell D., Stebbing J. Aristolochia: the malignant truth. Lancet Oncol., 2013;14(1): 25–6.
  12. Ahmedov R.B. Rasteniya – tvoi druz`ya i nedrugi. Ufa: Kitap, 2006; 313. [Ahmedov R.B. Plants - your friends and foes. Ufa: Kitap, 2006; 313. (in Russian)].
  13. Meenatchisundaram S., Parameswari P.G., Subbraj T. Studies on antivenom activity of Andrographis paniculata and Aristolochia indica plant extracts against Echiscarinatus venom. Int. J. Toxicol., 2009; 6:1.
  14. Das R., Kausik A., Pal T.K. Anti-inflammatory activity study of antidote Aristolochia indica to the venom of Heteropneustes fossils in rats. J. Chem. Pharm. Res., 2010; 2: 554–62.
  15. Kumar M.S., RajeswariA., Astalakshmi N. Evaluation of antimicrobial activities of Aristolochia indica (Linn). Inter. J. Pharm. Pharmaceut. Sci., 2011; 3: 271–2.
  16. Jiménez-Arellanes A., León-DíazR., Meckes M., TapiaA., Molina Salinas G.M., Luna HerreraJ., Yépez-MuliaL. Antiprotozoal and antimycobacterial activities of pure compounds from Aristolochia elegans rhizomes. Evidence- Based Complementary and Alternative Medicine, 2012; 1–7.
  17. Sulyman A.O., Akolade J.O., Sabiu S.A. Antidiabetic potentials of ethanolic extract of Aristolochia ringens. Journal of Ethnopharmacology, 2016; 182: 122–8.
  18. Homeopathisches Arzneibuch (HAB). Stuttgart: Deutscher Apotheker Verlag; 2010: 568.
  19. Debelle F.D., Vanherweghem J.L., Nortier J.L. Aristolochic acid nephropathy: a worldwide problem. Kidney Int., 2008; 74 (2): 158–69.
  20. Randy L., Perazella A.M. Aristolochic Acid Nephropathy: Epidemiology, Clinical Presentation, and Treatment. Drug Safety, 2015; (38): 55–64.