PROCEDURES FOR PREPARING LIPOSOMAL CARRIERS WITH ANTIOXIDANT ACTIVITY

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DOI: https://doi.org/None
Issue: 
5
Year: 
2017

A.A. Novikovа (1), P. Kezimana (1), A.I. Marakhova PhD, (1) E-mail: agentcat85@mail.ru, Professor A.A. Sorokina (2), PhD 1-Institute of Biochemical Technology and Nanotechnology, People’s Friendship University of Russia; 6, Miklukho-Maklai St., Moscow 117198, Russian Federation; 2-I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991, Russian Federation

The paper presents procedures for preparing liposomal drugs and highlights the advantages and disadvantages of the existing methods. It considers the problems associated with technology of hydrophobic antioxidants (the low solubility and chemical stability of these pharmacological substances) and the advantages of liposomes for their delivery. The most promising technology for obtaining liposomes with drug substances having antioxidant properties has been ascertained to be a thin-film hydration method, followed by vocalization.
Keywords: 
antioxidants
liposomes
phospholipids
directed transport
thin-film hydration method
sonication
References: 
  1. Haley B.,Frenkel E. Nanoparticles for drug delivery in cancer treatment. Urologic Oncology: Seminars and Original Investigations, 2008; 26: 57–64.
  2. Barenholz Y. Liposome application: problems and prospects. Curr. Opin. Colloid Interface Sci., 2001; 6: 66–77.
  3. Basu M.K. Liposomal delivery of antileishmanial agents. Journal of Applied Research., 2005; 5 (1): 221–236.
  4. Vasir J.K., Reddy M.K., Labhasetwar V.D. Nanosystems in drug targeting: opportunities and challenges. Current Nanoscience, 2005; 1 (1): 47–64.
  5. Demina N.B. B HYPERLINK «http://elibrary.ru/keyword_items.asp?keywordid=3052917»iopharmacy – the path to creating innovative medicines. Drug development and registration, 2013; 2 (2): 8–13 (in Russian).
  6. Thanos C.G., Emerich D.F. Choroid Plexus Epithelial Cell Transplants for Repair of the Brain. Cellular Transplantation, 2007; 399–416.
  7. Ulrich A.S. Biophysical aspects of using liposomes as delivery vehicles. Bioscience Reports., 2002; 22 (2): 129–150.
  8. Tong R., Boucher Y., Kozin S. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res., 2004; 64: 3731–6.
  9. Fenske D.B., Cullis P.R. Liposomal nanomedicines. Expert Opin. Drug Deliv., 2008; 5(1): 25–44.
  10. Mukhamadiarov R.A., Veremeev A.V., Martsiyash N.Y., Zinchuk V.G. The α-tocopherol influence to the lipoperoxidation process in the liposomes (in different storage temperatures) produced using ultrasonic sonification and extrusion methods. Fundamental research., 2012; 6: 566–70 (in Russian).
  11. Uhumwangho M.U., Okor R.S. Current trends in the production and biomedical applications of liposomes: a review. JMBR: A Peer-review Journal of Biomedical Sciences,2005; 4 (1): 9–21.
  12. Frezard F. Liposomes: from biophysics to the design of peptide vaccines. Braz. J. Biol. Res.,1999; 32 (2): 181 – 9.
  13. Mukhamadiarov R.A., Bogdanov M.V., Toropova Ya.G. The study of antioxidant activity and lipid peroxidation with the administration of various liposomes with antioxidants. Modern high technologies, 2010; 12: 38–48 (in Russian).
  14. Sanarova E.V., Kotova E.A., Lantsova A.V., Polozkova A.P., Oborotova N.A., Kozeev S.G., Krasnyuk I.I. Quality of liposomal phospholipids at different stages in the manufacturing process. Pharmaceutical Chemistry Journal., 2012; 46 (3): 50–3 (in Russian).
  15. Zabodalova L.A., Chernjavskij V.F., Ishchenko T.N., Skvortcova N.N. Production of liposomes from soybean lecithin. Scientific Journal., NRU ITMO, 2011; 2: 75–81 (in Russian).
  16. Mukhamadiarov R.A., Krivaya E.V., Kruch M.A., Plotnikov M.B. The evaluation of membrane-stabilizing effect of liposomes with different antioxidant drugs in osmotic hemolysis model. Modern problems of science and education, 2012; 4: 2827 (in Russian).
  17. Zaitsev V.G. Model systems of lipid peroxidation and their application for the evaluation of the antioxidant effect of drugs.Thesis for a scientific degree. Volgograd; 2001 (in Russian).
  18. Tadolini B., Franconi F. Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism. Free Radical Res., 1998; 29 (5): 377–87.
  19. Plumb G.W., De Pascual-Teresa S., Buelga C.S., Cheynier V., Williamson G. Antioxidant properties of catechins and proanthocyanidins: Effect of polymerisation, galloylationand glycosylation Free Radical Res., 1998; 29 (4): 351–8.
  20. Sandip B.T., Udupa N., Rao B.S.S., Devi P.U. Thermo sensitive liposomes and localized hyperthermia – an effective bimodality approach for tumor management. Indian Journal of Pharmacology, 2000; 32: 214–20.