STANDARDIZATION OF SPIRULINA (SPIRULINA PLATENSIS) MASS-BASED SUPPOSITORIES
DOI: https://doi.org/None
Issue:
1
Year:
2015
Dietary spirulina (Spirulina platensis) biomass is one of the promising types of plant raw materials to design drugs having regenerating and antiinflammatory activities. A dosage form, such as suppositories, is commonly used to treat hemorrhoid and gynecological inflammatory diseases. To analyze dietary spirulina biomass-based suppositories, their standardization procedure has been developed. To determine the identity of the suppositories, the authors propose to identify the pigment phycocyanin and to use the spectral characteristics of β-carotene and phycocyanin. Procedures have been devised for the spectrophotometric quantification of β-carotene and phycocyanin. The content of β-carotene and phycocyanin in the suppositories ranges from 0.80 mg to 1.35 mg% and from 0.20 to 0.33%, respectively.
Keywords:
dietary spirulina (Spirulina platensis)
biomass
β-carotene
phycocyanin
suppositories
standardization
spectrophotometry
References:
- Buzovskiy A.N., Kazaryan I.A. Razrabotka sostavov i tehnologii suppozitornyh osnov difil`nogo tipa. Farmaciya, 1988; 5: 21–23.
- Gosudarstvennaya farmakopeya SSSR XI izdaniya, vyp.2. M.: Medicina, 1990; 400.
- Dranik L.I. Myagkie lekarstvennye formy i vspomogatel`nye veshhestva dlya ih proizvodstva. Farmac. zhurn, 1990; 3: 45–47.
- Kurkin V.A. Osnovy fitoterapii. Samara: OOO «Ofort»; GOU VPO «SamGMU Roszdrava», 2009: 963.
- Mashkovskiy M.D. Lekarstvennye sredstva. 15-e izd. M.: «Novaya volna», 2008; 1200
- Pervushkin S.V., Voronin A.V., Sohina A.A. Biomassa spiruliny: issledovaniya i perspektivy ispol`zovaniya. Samara: SamGMU, 2004; 100.
- Rivkin V.L., Dul`cev Yu.V., Kapuler L.L. Gemorroy i drugie zabolevaniya zadneprohodnogo kanala. M.: Medicina, 1994; 240.
- Samylina I.A. Problemy standartizacii lekarstvennogo rastitel`nogo syr`ya i lekarstvennyh rastitel`nyh sredstv. Tradicionnaya medicina i pitanie: teoreticheskie i prakticheskie aspekty. Materialy I Mezhdunarodnogo nauchnogo kongressa. M.: Institut tradicionnyh metodov lecheniya MZ RF i dr., 1994; 254.
- Savel`eva G.M., Antonova L.V. Ostrye vospalitel`nye zabolevaniya vnutrennih polovyh organov zhenshhin. M.: Medicina, 1987; 160.
- Boussiba S., Richmond A. Isolation and purification of phycocyanins from the blue-green alga Spirulina platensis. Arch. Microbiol., 1979; 120: 155–159.