THE LEVEL OF URSOLIC ACID IN THE PLANTS OF THE GENUS PRIMULA

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DOI: https://doi.org/None
Issue: 
4
Year: 
2015

G.M. Latypova, PhD (1); Professor V.N. Bubenchikova (2), PhD; V.A. Kataev (1) 1 -Bashkir State Medical University; 3, Lenin St., Ufa 450000 2 -Kursk State Medical University; 3. K. Marx St., Kursk 305041

Drugs based on escin, an ester glycoside of oleanolic acid, are used as angioprotective and anticoagulant agents in medicine. The plants also contain the oleanolic acid isomer ursolic acid that has anti-inflammatory, hypolipidemic, and cytotoxic properties. Ursolic acid is shown to be present in primrose (Primula veris) and (Primula macrocalyx) herb. A spectrophotometric procedure has been developed to quantify the sum of triterpenic saponins in the raw materials, calculated with reference to ursolic acid, which accounts for 3.26 and 5.42%, respectively. The plants of the genus Primula are promising as an accessible Russian raw plant source of triterpenic saponins.
Keywords: 
cowslip primrose
Primula veris (P. officinalis (L.) Hill
Primula macrocalyx Bunge.
herb
triterpenoids
ursolic acid
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