INVESTIGATION OF THE DISPERSE COMPOSITION OF XYLOMETAZOLINE HYDROCHLORIDE NASAL SPRAY DROPLETS BY SHADOW PHOTOGRAPHY

Download full text PDF
DOI: https://doi.org/None
Issue: 
5
Year: 
2015

V.G. Yankova (1), PhD; S.V. Gribanova (1), PhD; I.L. Udyanskaya (1), PhD; I.I. Krasnyuk, Jr. (1), PhD; Yu.A. Lozhkin (2,3), O.A. Gobyzov (2,3) 1 -I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991 2 -Novosibirsk State University; 2, Pirogov St., Novosibirsk 630090 3 -S.S. Kutatelazde Institute of Thermal Physics, Siberian Branch, Russian Academy of Sciences; 1, Academician Lavrentyev Prospect, Novosibirsk 630090

The paper gives the results of examination of the particle size of 23 metered-dose xylometazoline hydrochloride nasal sprays of different trade names by blinker shadow photography. According to the disperse composition, all the sprays were differentiated into low- and moderate-disperse ones. Spray droplets in the test drugs were distributed by particle sizes; their distribution range was found to be from 5 to 150 μm. 15-to-30-μm droplets were shown to be a major fraction in all sprays.
Keywords: 
metered-dose nasal sprays
xylometazoline hydrochloride
particle size
particle size distribution
shadow photography
References: 
  1. Gubin M.M., Azmetova G.V. Novaya lekarstvennaya forma – sprey. Otlichiya ot ae`rozoley, osobennosti tehnologii proizvodstva. E`lektronnye resursy:http:// pharmspray/vipsmed.ru/publikacii/
  2. Novye razrabotki dlya analiza razmerov chastic farmacevticheskih spreev i ae`rozoley. Materialy kompanii «Malvern Instruments». Farmacevticheskaya otrasl`, 2013; 2(37): 72–75.
  3. Yankova V.G., Gribanova S.V., Udyanskaya I.L., Krasnyuk I.I., Rybina A.D. Razrabotka imitacionnyh modeley dlya ocenki kachestva raspyleniya lekarstvennoy formy «nazal`nyy dozirovannyy sprey» ksilometazolina gidrohlorida. Farmaciya, 2015; 3:29–32.
  4. Gosudarstvennaya Farmakopeya RF, XII izdaniya, chast` 2. M.: 2010; 132–137.
  5. Paul Kippax. Complementary techniques for nasal spray analysis. Equipment, jan/feb 2009:14-16.
  6. Njalling W. de Vries, Bart L. Rottier, Doetie Gjaltem, Paul Hagedoorn, Henderik W. Frijtink, Anne H. de Boer. Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution. Respiratory Medicine, 2009; 103:1167–1173.
  7. Kurbacheva O.M., Pavlova K.S., Kozulina I.E. Sovremennyy podhod k vyboru terapii bronhial`noy astmy: ot ponimaniya klinicheskih fenotipov k prakticheskim aspektam. Bolezni dyhatel`nyh putey. RMZh, 2013; 26:1–7.
  8. Ahmetbekov E.K., Bil`skiy A.V., Lozhkin Yu.A., Markovich D.M., Tyuryushkin A.N. Sistema upravleniya e`ksperimentom i obrabotki dannyh, poluchennyh metodami cifrovoy trassernoy vizualizacii (ActualFlow). Vychislitel`nye metody i programmirovanie. 2006; 7: 79–85.
  9. Markovich D.M., Pervunin K.S. Issledovanie struktury gazonasyshhennoy strui metodom lazerno-inducirovannoy fluorescencii. Vestnik Novosibirskogo gosudarstvennogo universiteta. Seriya: Fizika. 2007; 2 (3): 16–20.