HUMAN BIOCHEMICAL PASSPORT AS A TOOL FOR ASSESSMENT OF HUMAN HEALTH WELLBEING DURING CLINICAL TRIALS

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DOI: https://doi.org/None
Issue: 
5
Year: 
2015

E.G. Fokina, MD Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare; 3a, Novogireevskaya St., Moscow 111123

The paper provides a rationale for using a biochemical passport as a method to assess human health wellbeing during clinical trials. Advances in molecular biology and clinical biochemistry could substantiate an association between constants and enzyme systems in ensuring metabolic homeostasis. The role of 6 major biochemical constants (protein, albumin, glucose, cholesterol, urea, and creatinine) and 6 major enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, and creatine phosphokinase) in promoting good human health is considered. According to the present level of clinical trials, it is necessary to determine all 12 indicators in the human biochemical passport (in such a manner that all waves are estimated when analyzing ECG) and to compare them with the previous values of an individual.
Keywords: 
biochemical passport
drug pharmacokinetics
clinical trials
total protein
albumin
urea
creatinine
glucose
cholesterol
aspartate transaminase
alanine transaminase
alkaline phosphatase
gamma-glutamyl transferase
lactate dehydrogenase
creatine phosphokinase
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