INVESTIGATION OF THE DYNAMIC CHARACTERISTICS OF SPRAY OF METERED-DOSE XYLOMETAZOLINE HYDROCHLORIDE NASAL SPRAYERS BY A HIGH-SPEED SHADOW PHOTOGRAPHY METHOD

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DOI: https://doi.org/None
Issue: 
6
Year: 
2015

V.G. Yankova (1), PhD; S.V. Gribanova (1), PhD; I.L. Udyanskaya (1), PhD; I.I. Krasnyuk, Jr. (1), PhD; Yu.A. Lozhkin (2,3), O.A. Gobyzov (2,3) 1 -I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991 2 -Novosibirsk State University; 2, Pirogov St., Novosibirsk 630090 3 -S.S. Kutateladze Institute of Thermal Physics, Siberian Branch, Russian Academy of Sciences; 1, Academician Lavrentyev Prospect, Novosibirsk 630090

The spectrum of medical metered-dose nasal sprayers (MDNS) is being noticeably expanded and continuously increased. Spray characteristics, such as spraying dynamics and dispersion, play an important role in controlling the delivery and efficacy of a drug. The spraying dynamics of 23 metered-dose xylometazoline hydrochloride nasal sprays of different trade names was investigated by a high-speed shadow photography method. The investigators determined the quantitative characteristics of a spraying process, such as dispersion phases and their length, spray angle, and drug drop spray occupancy. The best spraying mode in view of all dynamic characteristics (the mean length of the basic spray phase; a geometrically wide and structurally hollow spray cone) ensures the most effective drug delivery to the nasal cavity. Comparative analysis of the dynamic characteristics could identify drugs with the best spraying mode.
Keywords: 
xylometazoline hydrochloride
metered-dose nasal sprayer
spraying dynamics
shadow photography method
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