RHEOLOGICAL PROPERTIES OF THE HYDROPHILIC BASES OF SOFT FORMULATIONS

Download full text PDF
DOI: https://doi.org/None
Issue: 
7
Year: 
2015

Yu.N. Molchanova; A.A. Trubnikov, PhD Yaroslavl State Medical Academy; 5, Revolyutsionnaya St., Yaroslavl 150000

The choice of rational technology of hydrophilic bases requires that the rheological properties of soft formulations should be studied. The performed investigations could compare the optimal concentrations of gelling agents in view of their viscosity values and characterize the test samples as disperse systems. The stability of hydrophilic bases was studied in all ranges of shear rates. The findings may be used to choose a hydrophilic base for the manufacture of soft formulations and for the prediction of technological parameters and consumer properties, such as tube filling and extrusion rates and usability and easiness to apply to the skin and mucosae.
Keywords: 
hydrophilic bases
rheological parameters
viscosity
shear stress
shear rate
References: 
  1. Pantyuhin A.V., Krasnyuk I.I. Reologicheskie modeli v uprugo-vyazkih lekarstvennyh formah. Sovremennye problemy nauki i obrazovaniya, 2013; 1.
  2. Roychowdhury Santanu, Singh Deep Hussan, Gupta Rajesh, Masih Daljit. A review on pharmaceutical gel. Int. J Pharm. Bio. Sci., 2012; 1 (5): 21–6.
  3. Molchanova Yu.N., Trubnikov A.A. Izuchenie reologicheskih parametrov gelevyh osnov, izgotovlennyh iz proizvodnyh cellyulozy. Razrabotka, issledovanie i marketing novoy farmacevticheskoy produkcii: sbornik nauchnyh trudov. 2014; vyp. 69: 139–142.
  4. Barsegyan M.A. Razrabotka sostava, tehnologii i obosnovanie norm kachestva rektal`noy mazi protivogemorroidal`nogo deystviya: Avtoref. dis. … kand. farm. nauk. 2011; 23.
  5. Volodina T.A. Razrabotka sostava, tehnologii i norm kachestva fitogelya reparativnogo deystviya: Avtoref. dis. … kand. farm. nauk. 2014; 23.
  6. Mustafin A.A., Nasybullina N.M., Pocelueva L.A. Issledovanie reologicheskih svoystv lekarstvennyh form meloksikama dlya naruzhnogo primeneniya. Uspehi sovremennogo estestvoznaniya, 2010; ; 11–14.
  7. Malkin A.Ya., Isaev A.I. Reologiya: koncepcii, metody, prilozheniya. SPb.: Professiya, 2010; 163–180.
  8. Molchanova Yu.N., Tolstova A.P. Polie`tilenglikoli razlichnyh molekulyarnyh mass v proizvodstve myagkih lekarstvennyh form. Sb. mater. IV Vseross. nauchn. konf. stud. i asp. s mezhdunarod. uchastiem «Molodaya farmaciya – potencial budushhego». SPb, 2014; 310–314.