USE OF THE HECKEL MATHEMATICAL MODEL TO SELECT THE OPTIMAL COMPACTION PRESSURE RANGE
DOI: https://doi.org/None
Issue:
8
Year:
2015
When designing the solid dosage form powders, of very great importance is their compatibility at a definite pressure, which is characterized by material properties, such as surface energy and deformation. The Heckel mathematical compaction model was used to conduct an investigation that determined the compaction pressure range and the mechanism for preparing high-quality kemantan tablets. An analysis revealed that particle fractionation and, possibly, redistribution were of paramount during compaction. The optimal compaction was in the range of 49 to 147 MPa.
Keywords:
Heckel equation
compaction
fragmentation
kemantan
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