PECULIARITIES OF PSYCHOTROPIC DRUGS ACTION ON CHANGES OF SPATIOTEMPORAL ATP CONCENTRATION GRADIENT IN NEURONS

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DOI: https://doi.org/None
Issue: 
8
Year: 
2015

Ya.R. Nartsissov, PhD, Associate Professor, E.V. Mashkovtseva, PhD, S.E. Boronovsky, PhD, V.S. Kopylova. Institute of Cytochemistry and Molecular Pharmacology, 6-th Radial’naya str., 24 14. Moscow, 115404, Russia

In some cases, mitochondrial dysfunctions, which are the main cause of different pathological process in tissues, may be initiated by psychotropic drugs therapy. Based on comparative analysis of ATP concentration changes, which were modeled in computer phantom of cerebral cortex neurons using mathematical modeling of nonsteady gradients of this nucleotide, it was shown that reduction of ATP sources amount caused decrease of the upper limit of nucleotide concentration regardless of active mitochondria geometrical arrangement. The decrease of ATP synthesis essentially reduces its level in neuroplasm with no possibility of fast recovering from the basic level without the activation of additional compensatory mechanisms. Toxic effect of psychotropic drugs leads to irreplaceable losses of cell energetic supply and may cause its further death.
Keywords: 
nonsteady gradients
diffusion
energetic supply of the cell
neuron
psychotropic drugs
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