PERSISTENCE OF ZOPICLONE IN LIVER TISSUE

DOI: https://doi.org/None
Issue: 
2
Year: 
2016

G.P. Chepurnaya Maikop State Technological University; 191, Pervomayskaya St., Maikop 38500

The authors investigated whether the hypnotic drug zopiclone persisted in cadaveric liver tissue when its samples were stored in different conditions. During the investigation, they employed a procedure involving a method for the extraction of substances from the biological material with acetone; primary purification through liquid extraction; additional purification and pre-identification via a TLC screening; and qualitative and quantitative UV-spectrophotometric analysis. Zopiclone as a rather stable on contact with cadaveric liver tissue persist at 5°С and 18–20°С for 3 months and may be isolated, identified, and quantified.

Keywords: 
zopiclone
liver tissue
extraction
persistence

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