FFFECT OF FRENCH MARIGOLD (TAGETES PATULA L.) EXTRACT ON WOUND HEALING IN RATS WITH EXPERIMENTAL DIABETES MELLITUS

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DOI: https://doi.org/None
Issue: 
3
Year: 
2016

E.M. Lomkina (1); N.M. Chervonnaya (2); D.V. Kurkin, MD (3); E.V. Bolotova (1), MD; D.A. Bakulin (2); Professor E.T. Oganesyan (2), PhD; O.A. Andreeva (2); Prof. I.N. Tyurenkov (1), MD 1 -Volgograd State Medical University; 1, Pavshikh Bortsov Square, Volgograd 400131 2 -Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University; 33, Kirov Pr., Pyatigorsk, Stavropol Territory 357500 3 -Research Institute of Pharmacology, Volgograd State Medical University; ??, Pavshikh Bortsov Square, Volgograd 400131

Impaired endothelial function and microcirculation in diabetes mellitus considerably slow down a wound healing process. Flavonoids having antioxidant activity improve endothelial function and stimulate angiogenesis. The wound-healing properties of an extract from French marigold flowers were determined in rats with experimental diabetes mellitus. The administration of the extract was shown to significantly accelerate a wound healing process in the animals with diabetes mellitus. A group of animals treated with French marigold extract showed a substantial reduction in the wound surface following 7 days and the wound size did not differ from that in the non-diabetes group after 21 days.
Keywords: 
diabetes mellitus
wounds
flavonoids
French marigold
Tagetes patula L.
French marigold extract
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