RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS OF GINGER (ZINGIBER OFFICINALE ROSCOE.) EXTRACT FROM CAPSULES

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DOI: https://doi.org/None
Issue: 
4
Year: 
2016

Professor N.B. Demina, PhD; A. Nader; M.N. Anurova, PhD; V.V. Smirnov, PhD; A.I. Bardakov, PhD; Professor I.I. Krasnyuk, PhD I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991

Objective: to investigate the effect of the type of capsules and a solubilizer on the release of biologically active substances (BAS) of ginger (Zingiber officinale Roscoe.) extract from its dosage form. Materials and methods. Gelatin and hydroxypropylcellulose (HPC) capsules, dry ginger extract (DGE), and the excipient that is a matrix polymer comprising of polyethylene glycol 6000, vinyl caprolactam, and vinyl acetate were the subjects of the investigation. The paper gives the results of the test «Solution» using spectrophotometry. Results and discussion. The comparable results of disintegration of gelatin and HPC capsules and release of BAS of DGE from them were shown. The solubility of DGE was found to increase in phosphate buffer at pH 6.8 in the presence of solubilizer. The incorporation of the solubilizer contributes to complete release; following 45 min, 97.5±3.8% of the active ingredients of the extract from both types of capsules convert to a solution. Conclusion. In terms of the main indicators (disintegration and release), gelatin and HPC capsules are close and comply with the pharmacopeia requirements. The excipient solubilizer incorporated into the granules with DGE has a positive effect on the dynamics of BAS release from capsules.
Keywords: 
solubilization
enhancement of solubility
ginger
Zingiber officinale Roscoe.
capsules
References: 
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