PROSPECTS FOR USING SOLID METHYLURACIL DISPERSIONS IN MEDICINE AND PHARMACY

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DOI: https://doi.org/None
Issue: 
5
Year: 
2016

V.V. Grikh, I.I. Krasnyuk, Jr., PhD; Professor I.I. Krasnyuk, PhD; A.V. Be-lyatskaya, PhD; O.I. Stepanova; T.M. Kosheleva; L.V. Ovsyannikova; O.N. Plakhotnaya, PhD; L.A. Korol, PhD; A.N. Galaiko I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991

Methyluracil dosage forms are commonly used in different fields of medicine. The oral route is the most effective route of administration for this drug substance. However, methyluracil is slightly soluble in water, which re-duces the biopharmaceutical characteristics of its based drugs. Analysis of the data available in the literature has shown that the preparation of solid disper-sions with methyluracil is a promising technology that can enhance the bioavailability of slightly soluble methyluracil, shorten its dissolution time, and improve its pharmaceutical parameters. The development of synthetic chemis-try, polymer chemistry in particular, provides possibilities to search for novel polymer combinations and to design solid dispersions.
Keywords: 
methyluracil
solid dispersions
polymers
solubility
bioavailability
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