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I.L. Udyanskaya, PhD; V.G. Yankova, PhD; T.K. Slonskaya, PhD; S.V. Gribanova, PhD; O.N. Plakhotnaya, PhD; I.I. Krasnyuk (Jr.), PhD; A.V. Khloponina; A.D. Rybina I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991, Russian Federation

Introduction. An active lifestyle, employment growth among the disabled, and development of sports, including the Paralympic movement, serve to increase the number of people who use prostheses following amputation. Introduction of biological active substances (BASs) with woundhealing, moistening, and antimicrobial properties into the silicone liners of prostheses makes them more comfortable. Objective. To investigate whether BASs may be incorporated into the silicone medical products applied in prosthetics. Materials and methods. The components for silicone liners, which had been provided by the Reutov Experimental Plant of Prosthetic Devices, Ministry of Labor of Russia, were used. Bisabolol and symdiol were selected as BASs. The bacteriostatic properties of the manufactured products were investigated using ready-made RIDA COUNT Total R1001 supports for routine microbiological tests, by determining the total number of microorganisms. Results and discussion. BASs should be incorporated into the base when manufacturing a silicone case of upper and lower limb stumps. A laboratory procedure has been developed to create simulation models of silicone liners, such as BAS-impregnated silicone disks (SDs). The optimal concentrations for introducing bisalol and symdiol, at which the products comply with the requirements of hardening completeness and nonstickness, have been established. The SDs with BASs have been shown to have a marked bacteriostatic activity. Even a short-term and low-intensity mechanical contact with the skin gives rise to the release of the introduced BAS that exerts a bacteriostatic effect on a broad spectrum of microorganisms. Conclusion. A laboratory procedure has been proposed to manufacture BAS-impregnated SDs. The products made have been shown to have a pronounced bacteriostatic activity.

silicone prosthetic liners
bacteriostatic activity

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