PROSPECTS FOR USING SOLID POLYVINYLPYRROLIDONE DISPERSIONS IN MEDICINE AND PHARMACY

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DOI: https://doi.org/None
Issue: 
6
Year: 
2016

I.I. Krasnyuk, Jr., PhD; A.V. Belyatskaya, PhD; Professor I.I. Krasnyuk, PhD; O.I. Stepanova; L.V. Ovsyannikova; V.V. Grikh; T.M. Allenova; E.B. Odintsova I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991, Russian Federation

To obtain solid dispersions is one of the promising areas for optimizing the biopharmaceutical properties of currently available drugs. To prepare them, polyvinylpyrrolidone with different molecular weights is widely used as a polymer carrier. The paper reviews the use of solid polyvinylpyrrolidone dispersions to prepare a number of drugs with optimized biopharmaceutical characteristics (the increased bioavailability of erythromycin, amikacin, metronidazole, rutin, quercetin, furacilin, derivatives of dihydropyridine, etc.).
Keywords: 
solid dispersions
polyvinylpyrrolidonee-10000
solubility
tablets
capsules
pharmaceutical technology
References: 
  1. Nikolaenko N.S., E`l`tanova M.I., Tregubova N.I. i dr. Sposob polucheniya mazi dlya mestnogo lecheniya gnoynyh ran. Patent RF №2097023. MKI A61K 9/06 /- №95118865/14.Zayavlen 15.11.1995; opublikovan 27.11.1997; 5.
  2. Krasnyuk I.I (ml.). Povyshenie biodostupnosti lekarstvennyh form s primeneniem tverdyh dispersiy. Dis. … doktora farmacevticheskih nauk. M., 2010; 200.
  3. Voskoboynikov A.V., Avakyan S.B., Sokol`skaya T.A. i dr. Sovremennye vspomogatel`nye veshhestva v proizvodstve tabletok. Ispol`zovanie vysokomolekulyarnyh soedineniy dlya sovershenstvovaniya lekarstvennyh form i optimizacii tehnologicheskogo processa. Himiko-farm. zhurn., 2005; 39 (1): 22–28.
  4. Mashkovskiy M.D. Lekarstvennye sredstva. 15-e izd. M.: Novaya volna, 2007; 1206.
  5. Sirotkin A.K., Piotrovskiy L.B., Poznyakova L.N. i dr. Vliyanie kompleksov fullerena S60 s polivinilpirrolidonom na morfologiyu virusov grippa. Voprosy biologicheskoy, medicinskoy i farmacevticheskoy himii, 2005; 3: 21–4.
  6. Tihobaeva A.A. Transdermal`naya sistema dostavki acetilsalicilovoy kisloty na osnove biosovmestimoy polimernoy matricy (e`ksperimental`noe issledovanie). Avtoref. dis. …kand. biol. nauk M., 2005; 24.
  7. Krasnyuk I.I., Krasnyuk I.I. (ml.), Popkov V.A. i dr. Sposob polucheniya tabletok e`ritromicina Patent RF № 2403049. MKI A61K31/7048, A61K47/00, A61K9/20, A61J3/10, A61P31/04/-№ 2009121316/15. Zayavleno 04.06.2009; opublikovano10.11.2010; 5.
  8. Koval`skiy I.V., Krasnyuk I.I., Krasnyuk I.I. (ml.) i dr. Sposob polucheniya tabletok rutina. Patent RF № 2523562. MKI A61K31/7048, A61K47/30, A61K9/20, A61J3/10/-№ 2013123463/15. Zayavleno 23.05.2013; opublikovano 20.07.2014; 5.