INVESTIGATION OF THE THERAPEUTIC EFFICACY OF LIPOSOMAL ACETYLCYSTEINE IN ACUTE LUNG INJURY

DOI: https://doi.org/None
Issue: 
6
Year: 
2016

O.A. Kulikov (1), MD; E.E. Marochkina (1); I.S. Dolgacheva (1); E.V. Semenova (1), MD; A.V. Kokorev (2), MD; Professor N.A. Pyataev (1), MD 1 -N.P. Ogarev Mordovian State University; 68, Bolshevistskaya St., Saransk 430005, Russian Federation 2 -National Research Nuclear University, Moscow Engineering Physics Institute, Ministry of Education and Science of Russia; 1, Studgorodok St, Obninsk, Kaluga Region 249040, Russian Federation

Introduction. The standard treatment for acute lung injury and acute respiratory distress syndrome is the use of glucocorticosteroids, dexamethasone in particular. According to some authors, liposomal antioxidants, including acetylcysteine, are able to reduce mortality from these diseases; however, the estimates of their efficacy compared to that of dexamethasone are contradictory. Objective: to compare the therapeutic efficacy of dexamethasone and liposomes with acetylcysteine in their use in case of acute exogenous lung injury. Material and methods. Acute lung injury was simulated by intratracheal injection of 0.1 ml/kg of acetone in 3 groups of outbred albino rats of both sexes, weighing 220-300 g. Group 1 animals were control; Group 2 received 0.4% dexamethasone solution; Group 3 was given liposomal acetylcysteine (L-ACC). The efficiency of the compared treatments was evaluated from the percentage of surviving animals, hemoglobin saturation, and pulmonary index. The results were statistically processed using the Student’s t-test and chi-square test. Results. Experimental data on trends in survival rates and hemoglobin saturation were obtained in experimental animals with acute lung injury when using different (dexamethasone or L-ACC) therapy regimens. Conclusion. L-ACC is effective in decreasing mortality from acute lung injury, in increasing blood oxygen saturation, and in reducing the degree of pulmonary edema. L-ACC versus dexamethasone is less effective in treating acute exogenous lung injury. The former has proven to improve respiratory system function and to reduce mortality rates.

Keywords: 
acetylcysteine
liposomes
dexamethasone
acute lung injury

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