AN ION-EXCLUSION CHROMATOGRAPHIC METHOD IN THE ANALYSIS OF PHARMACEUTICAL PREPARATIONS

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DOI: https://doi.org/None
Issue: 
7
Year: 
2016

A.N. Kuzmenko, PhD; I.I. Krasnyuk (Jr.), PhD; V.A. Popkov, PhD, PedD; O.V. Nesterova, PhD I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991, Russian Federation

The paper considers the theoretical bases of an ion-exclusion chromatographic method, used sorbents, eluents, and detectors employed in this type of liquid chromatography. The choice of eluents is due to the physicochemical mechanisms responsible for the separation of organic acids. That of a detector used in ion-exclusion chromatography depends on the task facing an analyst and on the required accuracy and sensitivity of test objects. The method is being increasingly used to test pharmaceutical preparations of synthetic as well as natural origin and to control their quality. The paper gives examples of using this method in pharmaceutical analysis. An increasing number of publications confirm the effectiveness of this chromatographic method.
Keywords: 
ion-exclusion chromatography
pharmaceutical preparations
quality control
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