Current aspects of the use of excipients as exemplified by transdermal therapeutic system technology

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DOI: https://doi.org/10.29296/25419218-2019-08-02
Issue: 
8
Year: 
2019

N.V. Shestakov(1), N.V. Pyatigorskaya(2) 1-Moscow Endocrine Plant; 25, Novokhokhlovskaya St., Moscow 109052, Russia; 2-I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia; 8-2, Trubetskaya St., Moscow 119991, Russia

The paper gives a classification of transdermal therapeutic systems (TTS). It considers the features of matrix and reservoir therapeutic systems, as well as their advantages, since TTS is one of the promising methods for drug delivery. Attention is paid to excipients; the classification of excipients and the requirements for the latter are given. Whether various excipients can be used in TTS is considered. The use of poloxamers, which are the block copolymers polyoxyethylene and polyoxypropylene, in the manufacture of drugs is a promising area for the application of excipients. Thus, further investigations of the design and introduction of new excipients for obtaining the TTC are very relevant.
Keywords: 
transdermal therapeutic system
advantages
disadvantages
excipients
requirements for excipients
innovative excipients
innovative use of a transdermal therapeutic system
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