Development of the composition and technology of vaginal suppositories containing a garden sage (Salvia officinalis) leaf extract

Introduction. Infectious and inflammatory diseases of the female genital organs impair the women’s reproductive health. The mainstay of treatment in these diseases is restoration of normal vaginal microbiocenosis, elimination of their pathogens, relief of inflammation, and general stimulation of the body. Natural antimicrobial agents used as intravaginal dosage forms are an alternative to topical synthetic antibacterial drugs. Objective: to develop the composition and technology of antibacterial vaginal suppositories containing a solid extract from the leaves of garden sage that grows in the Donbass region. Material and methods. The antimicrobial activity of a solid garden sage leaf extract as part of model mixtures with citric and benzoic acids and lactulose was determined by modified well agar diffusion. Suppository samples were prepared by pouring into suppository molds with a 3.0 nest volume. The quality of suppositories was assessed in accordance with the requirements of the 14th Edition of the State Pharmacopeia of the Russian Federation. Results. The investigators established the optimal composition for the incorporation of a solid extract garden sage leaf extract into the suppository base. It is rational to use polyethylene oxide bases. Conclusion. The composition of vaginal suppositories was developed for the treatment of gynecological infectious and inflammatory diseases, the choice of a suppository base and the optimal technology of vaginal suppositories that met the requirements of regulatory documentation were justified