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DOI: https://doi.org/10.29296/25419218-2020-02-07
Issue: 
2
Year: 
2020

L.G. Dvornikova, V.F. Turetskova, Yu.V. Korenovsky Altai State Medical University, 40, Lenin Pr., Barnaul 656038, Russian Federation

Introduction. Plant hepatoprotectors are actively used in the therapy of liver diseases. However, the range of medicines of this group, which are made in Russia, is small. Dry corn silk style and stigma extract is a promising hepatoprotective drug. Objective: to develop the composition of dry corn silk style and stigma extract-based capsules and their technology. Material and methods. The investigation object was dry corn silk style and stigma extract. The investigators determined the technological and physicochemical properties of the test extract: fractional composition, flowability, bulk weight, weight loss on drying, damping capacity, and hygroscopicity. Aerosil, lactose, ludipress, and magnesium oxide were used as excipients for capsulation. The experimental capsular masses were assessed by the degree of flowability and hygroscopicity, and the capsules were by the indicators «Disintegration» and «Dissolution». Results. The dry corn silk style and stigma extract has satisfactory flowability, but high hygroscopicity. Improvement in these parameters is favored by the addition of ludipress to the test extract in a ratio of 1:5. The resulting capsules disintegrate within 10 minutes; the dissolution of active ingredients exceeds 95%. Conclusion. Capsules with dry corn silk style and stigma extract can be prepared without prior granulation according to the recipe: dry extract 0.4; ludipress 0.08; size 0 gelatin capsules.
Keywords: 
corn silk styles and stigmas
dry extract
capsules
ludipress
References: 
  1. The incidence of the adult population of Russia in 2017. Statistical materials.Moscow: 2018; 3: 160 (in Russian).
  2. MatveevA.V. Hepatoprotectors. Analysis of international studies on drugs for the liver. Simferopol': IT «ARIAL»; 2013 (in Russian).
  3. Novikov V.E., Klimkina E.I. Pharmacology of hepatoprotectors. Reviews on clinical pharmacology and drug therapy. 2005; 4 (1): 2–20 (in Russian).
  4. Dvornikova L.G., Turetskova V.F. Study of phenolic compounds of corn silk gathered in Altai region. Khimiya rastitel'nogo syr'ya. 2013; 2: 127-134. https://doi.org/10.14258/jcprm.1302127 (in Russian).
  5. Dvornikova L.G., Turetskova V.F., Zamyatina S.V.et al. Corn silk dry extractas potential means of toxic hepatitises therapy. Izvestiya samarskogo nauchnogo tsentra Rossiiskoу akademii nauk, 2012; 5(3): 711–714 (in Russian).
  6. Alekseyev K.V., Blynskaya E.V., Suldin A.S., et al. Excipients in the technology of hard capsule. Farmatsiya, 2009; 5: 31–6 (in Russian).
  7. Archakova E.G., Neschislyaev V.A., Semchenko A.V., Molokhova E.I. Development of new pharmaceutical packet powder form of lactobacterin. Permskiу meditsinskiу zhurnal, 2008; 25 (2): 88–92 (in Russian).
  8. Murad A.T., Ruban Ye.A., Malynovskaya S.A. Selection of excipients for developing hard gelatin capsules with dry hop cones extract. Zb. nauk. prac' spіvrobіt. NMAPO іmenі P.L. SHupika, 2015; 24 (5): 158–62 (in Russian).
  9. Mashutin A.B., Blynskaya E.V., Suslina S.N., Alekseyev K.V. Development of structure and methods of standardization of capsules indapamide. Vestnik Rossiiskogo Universiteta Druzhby Narodov. Seriya: Meditsina. 2008; 3: 26–30 (in Russian).
  10. Molokhova E.I., Grigoryan L.G. The influence of technological parameters of Adjuncts on the quality of powders with bifidobacteria. Vestnik Rossiiskogo Universiteta Druzhby Narodov. Seriya: Meditsina. 2010; 4: 357–9 (in Russian).
  11. Bosenko L.G., Dvornikova L.G., Turetskova V.F. Perfection of a technique for quantitative spectrophotometric determination of flavonoids in corn silk. Aktual'nye problem farmakologii i farmatsii: an annual collection of scientific and methodological works of teachers, young scientists and students of the Faculty of Pharmacy. 2010; VII: 31–7 (in Russian).
  12. State Pharmacopoeia of the Russian Federation, XIV-th ed. [Electronic resource]. Access mode: http://femb.ru/feml (in Russian).
  13. Semkina O.A., Komkova S.P., Dzhavakhyan M.A. Technological aspects of development of capsules with anmarin for treatment of systemic mycosis. Zdorov'e i obrazovanie v XXI veke, 2018; 1: 216–21 (in Russian).
  14. British Pharmacopoeia. [Electronic resource]. Access mode: https://www.pharmacopoeia.com
  15. Mironov A.N. A guide to preclinical drug research. Moscow, Grif&Co; 2012. (in Russian).