Study of the wound healing effects of a gun oil sample on a rat skin wound model


E.I. Trofimets(1), Ya.A. Gushchin(1), K.L. Kryshen(1), M.N. Makarova(1), S.M. Mamykin(2) 1-Institute of Pre-Clinical Research Ltd, 3, Zavodskaya St., Build. 245, Kuzmolovsky Urban-Type Settlement, Vsevolozhsky District, Leningrad Region 188663, Russian Federation; 2-«Cupper» Ltd, 9, Godovikov St., Build. 5, Entrance 5.9, Floor 1, Room 1.8., Caliber Technopark, Moscow 125373, Russia

Introduction. Different types of wounds can be acquired not only in a combat zone, but also in everyday life. In the absence of specialized medicines at hand, it is very important to primarily manage injuries. Preliminary data show that some gun oil samples have wound healing properties, which may be of practical use in the field. Objective: to investigate the wound healing effect of a sample of CUPPER gun oil on a rat skin wound model. Material and methods. The investigation object was a sample of CUPPER weapons oil based on high-molecular-weight ethers with a complex copper-containing lubricant antiwear additive. The positive control drug was Methyluracil® that belongs to a pharmaceutical group of tissue repair stimulant. Male outbred rats were used as a test system. A skin wound was simulated in the area of animals’ withers. The course of the wound process was evaluated by clinical studies. A planimetric method was used to objectively assess wound healing. Results. Pronounced positive effects on the processes of tissue proliferation were observed when the oil sample was applied twice daily. An experiment revealed similar positive effects on the wound healing processes when applying Methyluracil® topically to the wound surface once daily and the test gun oil sample twice daily. The investigation results suggest that application of gun oil to the wound surface stimulates the regenerative processes. Conclusion. When topically applied, gun oil was found to have a wound healing effect on a male rat skin wound model, as confirmed by the results of a clinical observation of the course of the wound process and by those of planimetric and morphopathological studies.

gun oil
wound healing
laboratory animals

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