The composition and pharmacological action of biologically active substances in the plants of the genus Ferula

DOI: https://doi.org/10.29296/25419218-2021-02-01
Issue: 
2
Year: 
2021

O.A. Popova(1), G.M. Bobizoda(2), N.D. Bunyatyan(1, 3), I.P. Remezova(4), I.I. Samylina(3), A.B. Prokofyev(1), 3), V.A. Evteev(1), M.M. Sapovsky(3) 1-Research Center for Examination of Medical Products, Ministry of Health of the Russian Federation, 8, Petrovsky Boulevard, Moscow 127051, Russian Federation; 2-S. Aini Tajik State Pedagogical University, 121, Rudaki St., Dushanbe 733740, Republic of Tajikistan; 3-I.M. Sechenov First Moscow State Medical University (Sechenov University), 2, Bolshaya Pirogovskaya St., Build. 4, Moscow 119991, Russian Federation; 4-Pyatigorsk Medical and Pharmaceutical Institute, Branch, Volgograd State Medical University, 11, Kalinin Prospect, Pyatigorsk 357532, Russian Federation

Ferula has been used in folk medicine in the Central Asia countries, Iran, China, and India since ancient times. The genus Ferula plants widely distributed in Southern and Central Tajikistan contain terpenoid compounds, coumarins, esters of organic acids, peptides, carbohydrates, etc. The biologically active compounds contained in the genus Ferula plants exhibit various pharmacological activities: antioxidant, antileishmanial, anticonvulsant, antidiabetic, antispasmodic, antihypertensive, antinociceptive, and others. Ferulas are a rich source of gum resin that is widely used in traditional medicine of the peoples of the world. Gum resin possesses sedative, carminative, antispasmodic, expectorant, laxative, analgesic, anthelmintic, antiseptic, and diuretic activities and has aphrodisiac signs, owing to which it is used in animal husbandry to increase the fertility of livestock. The plants of the genus Ferula are promising raw materials for the design of novel highly effective medicines showing different pharmacological types of action.

Keywords: 
ferula
Ferula L
pharmacological activity
gum resin
terpenoid compounds
coumarins
carbohydrates
peptides

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