Creation and technological research of dental gel with tizol and L-arginine

DOI: https://doi.org/10.29296/25419218-2022-06-03
Issue: 
6
Year: 
2022

E.A. Samoshina(1), E.F. Stepanova(2), S.V. Poroyskiy(1), A.Yu. Saenko(2)
1-FSBEI HE Volgograd State Medical University of the Ministry of Health of Russia, 1, Pavshikh bortsov sq., Volgograd, 400131, Russian Federation;
2-Pyatigorsk Medical and Pharmaceutical Institute – branch of the FSBEI HE Volgograd State Medical University of the Ministry of Health of Russia, 11 Kalinin Ave., Pyatigorsk, Stavropol Territory, 357532, Russian Federation

Introduction. In recent years, considerable attention has been paid to the prevention and treatment of inflammatory diseases of the oral mucosa. Treatment of inflammatory diseases of the oral mucosa is the most difficult direction in modern dentistry, including due to the insufficient assortment of appropriate medicines and especially due to the small choice of dosage forms, rational and comfortable. In modern domestic medicine, soft dosage forms with anti-inflammatory effect and penetrating action are now of justified interest, however, a complex of auxiliary substances is important for activating their action, which is expressed, contributes to ensuring the effectiveness and safety of treatment. Objective: to develop the composition and technology of a dental gel with tizol and L-arginine in the treatment of inflammation of the oral mucosa, its biopharmaceutical and rheological studies. Material and methods. Tizol is an aquacomplex of titanium glycerosolvate, a metal complex compound with anti–inflammatory and antimicrobial action. L-arginine is an essential amino acid – a nitrogen donor. Inhibits the risk of pathogens and the formation of bacterial biofilms in the oral cavity. Auxiliary substances: methylcellulose, glycerin, PEG 1500, PEG 400, vaseline, lanolin, lecithin, carbopol 940. The studies were carried out using dialysis through a cellophane membrane, L-arginine was determined spectrophotometrically by reaction with ninhydrin, rheological parameters were determined on a Brookfield RVDV II+Pro rotary viscometer. Results. As a result of the conducted studies, it was shown that the optimal gel-forming agent for the tizol – L-arginine complex is PEG 1500 and PEG 400; rheological parameters determined the viscosity values for tizol from 16,000 Pa/s to 11.68 Pa/s; pharmacological studies in animals showed a decrease in the area of granulation tissue and an increase in the area of connective tissue against the background of applications with the developed gel compared to the control. Conclusion. For the first time, a dental gel based on tizol with L-arginine has been developed.
Keywords: 
dental gel
tizol
L-arginine
rheological characteristics
biopharmaceutical research
pharmacological research.
References: 
  1. Sichko A.I., Kobeleva T.A., Smagina T.A., Iliev K.I. Analysis of drugs of local anesthetic action in transdermal dosage forms with Tizol gel: methodological recommendations. Tyumen: TSMA, 2016; 44 (in Russian).
  2. Ayupova G.V. et al. Modern aspects of the development and improvement of the composition and technology of dosage forms. Medical Bulletin of Bashkortostan. 2016; 11, 5 (65): 87–90 (in Russian).
  3. Brazhnik E.A. Tizol in the complex treatment of erysipelas: materials of the X anniversary International scientific and practical conference of young medical scientists, February 26-27, 2016 Kursk, 2016; 99–101 (in Russian).
  4. Zalevskaya A.V., Zhilyakova E.T. Analysis of the basics of dental gels for the treatment of gingivitis. Scientific result. Series: Medicine and Pharmacy. 2016; 2, 1 (7): 53–8 (in Russian).
  5. Matyukhina M.V., Emelyanova I.V., Petrov A.Yu., Melnikov O.A. Investigation of the complexing properties of the basis of Tizol gel. Scientific bulletin of Belgorod State University. Series: Medicine. Pharmacy. 2017; 38, 12 (261): 112–9 (in Russian).
  6. Kuleshov S.M., Kuleshova T.G. The use of gels in medicine and veterinary medicine. Agrarian Bulletin of Primorye. 2016; 2 (2): 15–6 (in Russian).
  7. Makedonova Yu.A., Firsova I.V., Afanasyeva O.Yu. et al. Non-drug methods of treatment of erosive and ulcerative lesions of the oral cavity (review article). Volgograd Scientific Medical J. 2016; 1: 8–10 (in Russian).
  8. Ovechkina M.V. The study of pathomorphological changes in gum tissue in the treatment of chronic inflammatory and inflammatory-destructive periodontal diseases using a regenerative method based on autologous platelet plasma. 4.II. Periodontology. 2015; 20, 3 (76): 23–6 (in Russian).
  9. Mikhalchenko D.V., Makedonova Yu.A., Poroysky S.V. et al. Features of microcirculation of the oral cavity in inflammatory and destructive diseases. Kuban Scientific Medical Bulletin. 2016; 4: 85–9 (in Russian).
  10. Pozdnyakova T.A. The main directions of improving the technology of manufacturing and quality control of ointments. Actual problems in modern science and ways to solve them: a collection of articles based on the materials of the international scientific and practical conference. 2016; 3 (24), part 4: 153–5 (in Russian).
  11. Samoshina E.A., Stepanova E.F., Poroyskiy S.V. Anti-inflammatory external medicines: use in dentistry. J. Pharmaceutical business and technology of medicines, ed. Panorama. 2022; 1: 55–9 (in Russian).
  12. Fedotova Yu.M., Makedonova Yu.A., Poroysky S.V. et al. Modern aspects of the treatment of erosive ulcerative form of lichen planus of the oral mucosa: [Electronic resource]. Modern problems of science and education. 2016; 2. Access mode: URL: http://www.science-education.ru/article/view?id=24325 (in Russian).
  13. Hurtina A.S., Burtseva T.V. Incompatibility of medicines (literature review). J. Youth and Science. 2019; 2: 48 (in Russian)