Formation and development of the biopharmaceutical doctrine of creating effective medicines

DOI: https://doi.org/10.29296/25419218-2022-07-01
Issue: 
7
Year: 
2022

N.B. Demina, A.I. Bardakov, I.I. Krasniuk
I.M. Sechenov First Moscow State Medical University (Sechenov University), A.P. Nelyubin Institute of pharmacy, Vernadsky avenue 96, building 1, Moscow, 119571, Russian Federation

The article considers the stages of formation and development of Biopharmacy as a scientific direction in Russia. One of the founders of biopharmacy was Corresponding Member of the Russian Academy of Medical Sciences, Professor A.I. Tentsova. Under her leadership, the All-Union Scientific Research Institute of Pharmacy began studying pharmaceutical factors that affect the effectiveness of drugs, determining bioavailability and bioequivalence, created a pharmacopeialmonograph for the Dissolution test, and began developing new dosage forms based on liposomes, microcapsules, solid dispersions. Biopharmaceutical concepts are now well recognized and they have found their application in pharmaceutical development, quality assessment and drug efficacy. The article provides an overview of modern biopharmaceutical research currently being carried out in universities and scientific organizations of the Russian Federation. The contribution of Russian scientists to the development of areas of biopharmaceutical doctrine is: the creation of dosage forms of the latest generations based on nano- and microcarriers, with prolonged, modified release, targeted action, etc.; study of pharmacokinetics and bioequivalence of drugs; methodology for conducting the Dissolution test, etc. Today, biopharmacy has become part of the educational process of preparing pharmacists, as well as one of the areas of scientific research for highly qualified specialists, which is reflected in the passports of scientific specialties. Biopharmacy, logically combining various pharmaceutical areas in favor of the patient, has become fundamental in the creation of effective and safe medicines.
Keywords: 
biopharmacy
dosage forms
pharmaceutical factors
dissolution test
drug technology
history of pharmacy
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