Theoretical and practical development of the composition of intranasal dosage forms with the active component of ginko biloba extract

DOI: https://doi.org/10.29296/25419218-2022-07-04
Issue: 
7
Year: 
2022

E.V. Kovtun(1), Е.F. Stepanova(1), L.V. Pogrebnyak(1), Т.N. Glizhova(2), А.V. Pogrebnyak(1), D.О. Bokov(3)
1-Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532, Russian Federation;
2-Federal State Autonomous Educational Institution of Higher Education "North Caucasian Federal University", Pushkin St. 1, build. 3, Stavropol, 355000, Russian Federation;
3-A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., build. 2, Moscow, 119991, Russian Federation

Introduction. The successful use of herbal remedies for the treatment and prevention of a number of diseases is beyond doubt, which is primarily due to their high biological activity. A pronounced action of a complex of substances is noted, in comparison with the action of an individual substance. Nootropics are no exception, the market of which is dynamically growing. That is why the choice of objects of plant origin, which have an effect on cerebral circulation, on the state of blood vessels, seems promising to us. Models based on Ginkgo biloba extract fit into this problem, but careful choice of dosage form is required. Nasal dosage forms have a number of advantages, the main ones are high bioavailability, the possibility of systemic action of medicinal substances and the speed of its development, active absorption of a number of medicinal substances can occur in the nasal cavity, which are cleaved in the gastrointestinal tract, and their maximum concentration in the blood is reached quickly. Objective. The aim of our work is technological studies of the intranasal dosage form – drops, including the theoretical and experimental selection of a group of excipients, as well as their interaction with the active complex of Ginkgo biloba. Material and methods. When creating an intranasal dosage form based on a phytocomposition, various research methods were used: technological, biopharmaceutical, physical, physicochemical, microbiological. In addition, the semi-empirical method of PM7 molecular orbitals was used. Results. Theoretical and experimental studies on the choice of excipients for intranasal dosage form have been carried out. Conclusion. The conducted studies prove the feasibility of developing a technology for a dosage form – drops in the form of an emulsion with active components of Ginkgo biloba.
Keywords: 
intranasal delivery
thick ginkgo biloba extract
drops
emulsion
flavonoids
ginkolides
computer molecular modeling
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