Technological studies of intranasal dosage forms with ginkgo biloba phytocomplex and the possibility of their standardization

DOI: https://doi.org/10.29296/25419218-2023-02-05
Issue: 
2
Year: 
2023

E.V. Kovtun(1), D.О. Bokov(2, 3), A.B. Samoriadova(1), A.S. Chiriapkin(1), A.L. Petrova(1),
1-Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532, Russian Federation;
2-Sechenov First Moscow State Medical University (Sechenov University), st. Trubetskaya, 8, bldg. 2, Moscow, 119991, Russian Federation;
3-Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”, Ustinsky proezd, building 2/14, Moscow, 109240, Russian Federation

Introduction. The second decade of the 21st century is filled with significant pharmaceutical science and manufacturing events, since it is in this period, a new concept began to be implemented, linking all the stages pharmaceutical development into a single continuous chain, from theoretical calculations, pharmacological tests, design composition of dosage forms up to the stage of implementation of innovative medicines. In parallel, society has faced new challenges, such as a pandemic, climate change and environmental pollution, which have a significant impact on people's health. These circumstances affected the domestic pharmaceutical industry and required an urgent and large-scale expansion of the range of dosage forms, including import substitution. This also applies to the rational use of natural resources, especially medicinal plants, the raw material base and the range of which is very voluminous. Intranasal dosage forms today make up a significant percentage of innovative dosage forms, although it is not yet possible to draw conclusions about their comprehensive study. First of all, this applies to phytocompositions for intranasal administration. This direction certainly needs detailed and versatile study. Objective: technological research intranasal dosage forms, including the development of technology, as well as their standardization by one indicator. Material and methods. When creating intranasal dosage forms on Based on the phytocomposition, as well as their standardization, various research methods were used: technological, biopharmaceutical, physical, physicochemical. Results. Quality standards for intranasal dosage forms have been developed. Methods for determining the active substances in intranasal gel and drops, the amount of flavonoids in terms of the major component are proposed. Conclusion. Conducted studies prove the feasibility development of technology for dosage forms and assessment of their quality by the amount of flavonoids.
Keywords: 
intranasal delivery
thick ginkgo biloba extract
dry ginkgo biloba extract
intranasal drops
intranasal gel
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