Theoretical and practical development of dental films based on chitosan

DOI: https://doi.org/10.29296/25419218-2023-05-06
Issue: 
5
Year: 
2023

E.V. Kovtun(1), E.F. Stepanova(1), L.V. Pogrebnyak(1), A.V. Pogrebnyak(1), D.O. Bokov(2, 3), N.P. Balobanova(4), E.B. Bryuzgina(5), O.V. Kolyaganova(5),V.V. Klimov(5), E.V. Bryuzgin(5), I.A. Samylina(2)
1-Рyatigorsk Medical and Pharmaceutical Institute-branch of the Federal State Budgetary Educational Institution of the Ministry of Health of the Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532, Russian Federation;
2-A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, Trubetskaya St., 8, bldg. 2, Moscow, 119991, Russian Federation;
3-Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”, Ustinsky proezd, building 2/14, Moscow, 109240, Russian Federation
4-Department of Pharmacy, University "Synergy", Leningradsky Prospekt, 80, Moscow, 125190, Russian Federation;
5-Volgograd State Technical University, V.I. Lenina, 28, Volgograd, 400005, Russian Federation

Introduction. An analysis of the current state of research in the field of creating dental films shows the need to search for new polymer bases for their production. One of the modern approaches is the combination of phytocomplexes with polymers with biological activity. Such a promising polymer, in our opinion, is chitosan, a derivative of the polysaccharide chitin and a large-tonnage product of the processing of the latter. It has a number of advantages, providing a prolonged effect and the ability to stay on the mucous surface for a long time. Another promising component of dental products is the biologically active components of ginkgo extract. Objective. Development of theoretical and practical methods for the production of dental films based on chitosan and evaluation of their ability to absorb biologically active components of herbal preparations. Material and methods. Chitosan (Bioprogress, М=200 kDa, degree of deacetylation – 83%, bulk density – 1.5 g/cm3); molding of film materials according to the standard method, HLB evaluation by the Davis method, molecular modeling by molecular mechanics and quantum chemistry (academic license of the HyperChem8 molecular modeling program (HyperCube (C)), academic license No. HC80SA-4-1BBF6). The strength properties of the films were determined on a ZwickiLine tensile testing machine. Soil degradation was determined in laboratory conditions, according to GOST 9.060-75 Results. Dental films based on chitosan were obtained by dissolving chitosan in water in the presence of acetic acid, followed by conversion from the acidic to the basic form with an ammonia solution and subsequent drying in a thin layer. Previously obtained extract of ginkgo was introduced either in the pre-drying stage, or by applying directly to the film. Theoretical modeling of the adsorption of biologically active components of ginkgo extract on the surface of chitosan by the semi-empirical method of quantum chemistry PM7 has been performed. The physicochemical characteristics of the films in various media, as well as their strength and biodegradation, were studied. Conclusion. The properties of dental films based on chitosan polymer have been described theoretically and experimentally, have the necessary technological characteristics and can be used as promising dental dosage forms, including those containing ginkgo extract.
Keywords: 
dental films
ginkgo extract
molecular modeling.
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